Targretin Gel Side Effects

Generic name: bexarotene topical

Note: This document contains side effect information about bexarotene topical. Some of the dosage forms listed on this page may not apply to the brand name Targretin Gel.

Some side effects of Targretin Gel may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to bexarotene topical: topical gel

Get emergency medical help if you have any of these signs of an allergic reaction while taking bexarotene topical (the active ingredient contained in Targretin Gel) hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using bexarotene topical and call your doctor at once if you have:

• severe skin irritation (pain, burning, stinging, itching) after applying this medication;

• severe skin rash or redness; or

• swelling, bleeding, or tearing of treated skin.

Common side effects may include:

• mild burning, stinging, or itching;

• mild pain, redness, or irritation; or

• skin dryness or peeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to bexarotene topical: topical gel

Dermatologic

Dermatologic side effects have included rash (56% to 72%), pruritus (18% to 36%), skin disorder (18% to 26%), contact dermatitis (8% to 14%), exfoliative dermatitis (6%), maculopapular rash (6%), and sweating (6%).

General

General side effects have included headache (14%), asthenia (6%), infection (18%), and pain (30%).

Metabolic

Metabolic side effects have included hyperlipidemia in 10% of patients.

Cardiovascular

Cardiovascular side effects have included edema (10%) and peripheral edema (6%).

Hematologic

Hematologic side effects have included leukopenia and abnormal WBC each reported in 6% of patients.

Other

Lymphatic side effects have included lymphadenopathy (6%).

Nervous system

Nervous system side effects have included paresthesia (6%).

Respiratory

Respiratory side effects have included increased cough and pharyngitis in 6% of patients.

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