Talwin Nx Side Effects
Generic Name: naloxone / pentazocine
Note: This page contains side effects data for the generic drug naloxone / pentazocine. It is possible that some of the dosage forms included below may not apply to the brand name Talwin Nx.
It is possible that some side effects of Talwin Nx may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to naloxone / pentazocine: oral tablet
As well as its needed effects, naloxone / pentazocine may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking naloxone / pentazocine, check with your doctor immediately:Rare
- Black, tarry stools
- chest pain
- cough or hoarseness
- difficult or troubled breathing
- fever with or without chills
- general feeling of tiredness or weakness
- irregular, fast or slow, or shallow breathing
- lower back or side pain
- painful or difficult urination
- pale or blue lips, fingernails, or skin
- shakiness in the legs, arms, hands, or feet
- shortness of breath
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- swollen glands
- trembling or shaking of the hands or feet
- unusual bleeding or bruising
- unusual tiredness or weakness
- Blistering, peeling, or loosening of the skin
- blurred vision
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- decrease in the frequency of urination
- difficulty in passing urine (dribbling)
- difficulty with swallowing
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast, slow, pounding, or irregular heartbeat or pulse
- feeling of warmth
- joint or muscle pain
- loss of bladder control
- loss of consciousness
- pounding in the ears
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid breathing
- red skin lesions, often with a purple center
- red, irritated eyes
- redness of the face, neck, arms, and occasionally, upper chest
- skin rash
- swelling of the lower legs or arms
- swelling of the face
- tightness in the chest
- total body jerking
- upper abdominal or stomach pain
- weight gain
If any of the following symptoms of overdose occur while taking naloxone / pentazocine, get emergency help immediately:Symptoms of overdose
- Seeing, hearing, or feeling things that are not there
- seizures (convulsions)
- sleepiness or unusual drowsiness
Some naloxone / pentazocine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:Rare
- Abdominal or stomach distress
- hives or welts
- redness of the skin
- Blistering, crusting, irritation, itching, or reddening of the skin
- confusion about identity, place, and time
- constricted, pinpoint, or small pupils (black part of the eye)
- continuing ringing or buzzing or other unexplained noise in the ears
- cracked, dry, or scaly skin
- difficulty in focusing the eyes
- disturbed dreams
- dry mouth
- false or unusual sense of well-being
- hearing loss
- loss of appetite
- mood or mental changes
- relaxed and calm feeling
- trouble with sleeping
- unable to sleep
- weight loss
For Healthcare Professionals
Applies to naloxone / pentazocine: oral tablet
A 45-year-old male narcotic addict and alcoholic with hepatitis and undiscovered cardiomyopathy was given 0.8 mg of naloxone intravenously over a 2 minute period and developed ventricular fibrillation. The patient required naloxone once more for this episode and again developed ventricular fibrillation. A second opioid overdose in the same patient was treated with an initial dose of 0.4 mg intravenously, followed by 0.4 mg intravenously, then intramuscularly. Each time the patient developed ventricular fibrillation responsive to cardioversion and/or lidocaine.
Severe hypertension (mean arterial pressure rising from a baseline of 107 mmHg to 147 mmHg in about 2 to 3 hours) has been reported in an essential hypertension patient given an initial 8 mg dose of naloxone intravenously, followed by an infusion of 0.13 mg/min over the next 2.5 hours. When the naloxone was discontinued the blood pressure quickly returned to normal.
Mild hypotension and one case of moderate hypertension were observed in patients receiving a bolus dose of 4 mg/kg of naloxone followed by 2 mg/kg/hour for 24 hours. One study reported that the newborn infants of mothers who have received naloxone near term may experience tachycardia.
Cardiovascular side effects with the use of naloxone have included hypotension, hypertension, atrial and ventricular tachycardia, ventricular fibrillation, left ventricular failure and cardiac arrest (mostly in postoperative patients, many of whom had cardiovascular disease).
Cardiovascular side effects including a decrease in blood pressure and tachycardia have been reported infrequently with the use of pentazocine.
Withdrawal syndromes from the use of naloxone may be precipitated by as little as 0.05 to 0.2 mg intravenously in patients taking 24 mg per day of methadone.
Other side effect including withdrawal in patients receiving opioids have been precipitated by naloxone. Withdrawal is characterized by nausea, vomiting, sweating, lacrimation, rhinorrhea, cramping, insomnia, chills/hot flashes, piloerection, tachycardia, anxiety, restlessness, irritability, tremulousness, hypertension, seizures, and cardiac arrest. Similar symptoms have been noted in patients with pruritus of cholestasis who were not receiving opiates.
Other side effects including tinnitus have been reported with the use of pentazocine.
Three cases, treated with numerous drugs, developed clinical evidence of pulmonary edema shortly after intravenous administration of naloxone (0.3 to 1.6 mg).
Respiratory side effects including pulmonary edema have been uncommon from the use of naloxone.
Respiratory side effects including respiratory depression have rarely been reported with the use of pentazocine.
A 51-year-old male was given 0.8 mg of naloxone for obtundation. Within 30 seconds of administration a grand mal seizure occurred. The patient had Pseudomonas sepsis with negative CSF cultures.
Nervous system side effects including seizures and paresthesias have been reported at both standard and high dosages of naloxone. Seizures have been reported in 5% of patients receiving a bolus of 4 mg/kg followed by 2 mg/kg/h for 24 hours. Agitation has been noted in 3%, tremors in 3%, and headache in 5%. Rarely, agitation, tremors, headache, alteration in mood and cognition, mental discomfort, sleepiness, and confusion have been reported at high dosages. Lethargy has been reported in manic and control patients. Naloxone administration may worsen obsessive compulsive behavior.
Nervous system side effects including sweating, dizziness, lightheadedness, hallucinations, sedation, euphoria, headache, confusion, and disorientation have been reported with the use of pentazocine. Weakness, flushing, disturbed dreams, insomnia, and syncope have been reported infrequently. Tremor, chills, paresthesia, irritability, and excitement have been reported rarely.
Nausea and/or vomiting occurred in 32% of patients in one study on naloxone who received a bolus of 4 mg/kg followed by 2 mg/kg/h for 24 hours.
Gastrointestinal side effects of nausea and vomiting have been reported in patients receiving high dose naloxone therapy.
Gastrointestinal side effects including nausea and vomiting have been reported with the use of pentazocine. Constipation has been reported infrequently. Abdominal distress, anorexia, and diarrhea have been reported rarely.
Genitourinary side effects including an increase in urinary urgency have rarely been reported with the use of naloxone. The drug may also have a mild diuretic effect.
Genitourinary side effects including urinary retention have rarely been reported with the use of pentazocine.
A 75-year-old was treated with naloxone for senile dementia. A dosage of 0.8 mg in 25 mL of normal saline was given as an infusion over 10 minutes. The treatment was given 6 times, each time the patient experienced urinary urgency (at least 5 small volume urinations over 2 hours).
Depression of the white blood cell count is usually reversible.
Hematologic side effects including depression of the white blood cell count (especially granulocytes) and moderate transient eosinophilia have been reported with the use of pentazocine.
Hypersensitivity reactions including rash have been reported infrequently. Urticaria and edema of the face have been reported rarely with the use of pentazocine. One instance of an apparent anaphylactic reaction has been reported.
Dermatologic side effects including erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis have been reported rarely with the use of pentazocine.
Ocular side effects including visual blurring and focusing difficulty have been reported infrequently with the use of pentazocine.
Psychiatric side effects including depression have been reported infrequently with the use of pentazocine.
More about Talwin Nx (naloxone / pentazocine)
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