Tafinlar Side Effects

Generic Name: dabrafenib

Note: This document contains side effect information about dabrafenib. Some of the dosage forms listed on this page may not apply to the brand name Tafinlar.

Some side effects of Tafinlar may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to dabrafenib: oral capsule

Along with its needed effects, dabrafenib (the active ingredient contained in Tafinlar) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dabrafenib:

More common
  • Abdominal or stomach pain
  • bloody or cloudy urine
  • blurred vision
  • dry mouth
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • greatly decreased frequency of urination or amount of urine
  • increased hunger
  • increased thirst
  • increased urination
  • lump or growth on the skin
  • nausea
  • redness, swelling, or pain of the skin
  • scaling of the skin on the hands and feet
  • skin blisters
  • skin rash
  • sweating
  • swelling of the feet or lower legs
  • tingling of the hands and feet
  • troubled breathing
  • ulceration of the skin
  • unexplained weight loss
  • unusual tiredness or weakness
  • vomiting
Less common
  • Blurred vision or other change in vision
  • change in color vision
  • difficulty seeing at night
  • eye pain
  • increased sensitivity of the eyes to sunlight
  • redness of the eye
  • tearing

Some side effects of dabrafenib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Back pain
  • constipation
  • cough
  • darkened urine
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • fast heartbeat
  • hair loss or thinning of the hair
  • headache
  • indigestion
  • loss of appetite
  • muscle aches
  • muscle pain or stiffness
  • pain in the joints
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • sore throat
  • stuffy or runny nose
  • yellow eyes or skin

For Healthcare Professionals

Applies to dabrafenib: oral capsule


The most frequently reported side effects included hyperkeratosis, headache, pyrexia, arthralgia, papilloma, alopecia, and palmar-plantar erythrodysesthesia syndrome (PPES).

The most common side effect resulting in dose reduction were pyrexia (9%), PPES (3%), chills (3%), fatigue (2%), and headache (2%).


Very common (10% or more): Papilloma (27%)
Common (1% to 10%): Cutaneous squamous cell carcinoma (7%)


Very common (10% or more): Hyperkeratosis (37%), alopecia (22%), palmar-plantar erythrodysesthesia syndrome (20%), rash (17%)


Very common (10% or more): Constipation (12%)
Frequency not reported: Pancreatitis


Very common (10% or more): Pyrexia (28%)
Common (1% to 10%): Serious febrile drug reactions (3.7%)


Frequency not reported: Hypersensitivity manifesting as bullous rash


Very common (10% or more): Hyperglycemia (50%), hypophosphatemia (37%), increased alkaline phosphatase (19%)
Common (1% to 10%): Hyponatremia (8%)


Very common (10% or more): Arthralgia (27%), back pain (12%), myalgia (11%)

Nervous system

Very common (10% or more): Headache (32%)


Common (1% to 10%): Uveitis (1%)


Frequency not reported: Interstitial nephritis


Very common (10% or more): Cough (12%), nasopharyngitis (10%)

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