Tafinlar Side Effects

Generic Name: dabrafenib

Note: This page contains side effects data for the generic drug dabrafenib. It is possible that some of the dosage forms included below may not apply to the brand name Tafinlar.

It is possible that some side effects of Tafinlar may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to dabrafenib: oral capsule

As well as its needed effects, dabrafenib (the active ingredient contained in Tafinlar) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking dabrafenib, check with your doctor immediately:

More common
  • Abdominal or stomach pain
  • bloody or cloudy urine
  • blurred vision
  • dry mouth
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • greatly decreased frequency of urination or amount of urine
  • increased hunger
  • increased thirst
  • increased urination
  • lump or growth on the skin
  • nausea
  • redness, swelling, or pain of the skin
  • scaling of the skin on the hands and feet
  • skin blisters
  • skin rash
  • sweating
  • swelling of the feet or lower legs
  • tingling of the hands and feet
  • troubled breathing
  • ulceration of the skin
  • unexplained weight loss
  • unusual tiredness or weakness
  • vomiting
Less common
  • Blurred vision or other change in vision
  • change in color vision
  • difficulty seeing at night
  • eye pain
  • increased sensitivity of the eyes to sunlight
  • redness of the eye
  • tearing

Some dabrafenib side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Back pain
  • constipation
  • cough
  • darkened urine
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • fast heartbeat
  • hair loss or thinning of the hair
  • headache
  • indigestion
  • loss of appetite
  • muscle aches
  • muscle pain or stiffness
  • pain in the joints
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • sore throat
  • stuffy or runny nose
  • yellow eyes or skin

For Healthcare Professionals

Applies to dabrafenib: oral capsule

General

The most frequently reported side effects included hyperkeratosis, headache, pyrexia, arthralgia, papilloma, alopecia, and palmar-plantar erythrodysesthesia syndrome (PPES).

The most common side effect resulting in dose reduction were pyrexia (9%), PPES (3%), chills (3%), fatigue (2%), and headache (2%).[Ref]

Oncologic

Very common (10% or more): Papilloma (27%)
Common (1% to 10%): Cutaneous squamous cell carcinoma (7%)[Ref]

Dermatologic

Very common (10% or more): Hyperkeratosis (37%), alopecia (22%), palmar-plantar erythrodysesthesia syndrome (20%), rash (17%)[Ref]

Gastrointestinal

Very common (10% or more): Constipation (12%)
Frequency not reported: Pancreatitis[Ref]

Other

Very common (10% or more): Pyrexia (28%)
Common (1% to 10%): Serious febrile drug reactions (3.7%)[Ref]

Hypersensitivity

Frequency not reported: Hypersensitivity manifesting as bullous rash[Ref]

Metabolic

Very common (10% or more): Hyperglycemia (50%), hypophosphatemia (37%), increased alkaline phosphatase (19%)
Common (1% to 10%): Hyponatremia (8%)[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia (27%), back pain (12%), myalgia (11%)[Ref]

Nervous system

Very common (10% or more): Headache (32%)[Ref]

Ocular

Common (1% to 10%): Uveitis (1%)[Ref]

Renal

Frequency not reported: Interstitial nephritis[Ref]

Respiratory

Very common (10% or more): Cough (12%), nasopharyngitis (10%)[Ref]

References

1. "Product Information. Tafinlar (dabrafenib)." GlaxoSmithKline, Research Triangle Park, NC.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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