Synvisc Side Effects
Generic Name: hylan g-f 20
Note: This page contains side effects data for the generic drug hylan g-f 20. It is possible that some of the dosage forms included below may not apply to the brand name Synvisc.
It is possible that some side effects of Synvisc may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to hylan g-f 20: injection injectable, injection solution
As well as its needed effects, hylan g-f 20 (the active ingredient contained in Synvisc) may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking hylan g-f 20, check with your doctor or nurse as soon as possible:Rare
- Difficulty breathing
- shortness of breath
Some hylan g-f 20 side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common
- Knee pain
- pain at the injection site
- swelling of the knee
- Calf cramps
- facial flushing with swelling of the lips
- infection of the joint
- itching of the skin
- muscle pain
- pain on one side of the body with anxiety, nausea, and tiredness
- rapid heartbeat
- skin rash
For Healthcare Professionals
Applies to hylan g-f 20: intra-articular solution
A retrospective study reported pain, warmth, and swelling after 11% of injections, in some cases lasting up to 3 weeks.
In clinical trials with 511 patients who received a total of 1771 injections, knee pain and/or swelling were reported in 7.2% patients or 2.2% of injections and were the most common adverse reactions.
Dermatologic side effects have included individual cases of rash, itching, generalized urticaria, recurring small hives, facial flush with lip swelling, and body prickling. These symptoms did not reoccur upon rechallenge.
Gastrointestinal side effects have included nausea and hemorrhoids.
Pseudosepsis has been characterized as severe joint inflammation with pain and effusion occurring 24 to 72 hours after injection and it may be more likely to occur after the second or third injection or with repeated courses. Nonsteroidal anti-inflammatory drugs, intra-articular steroids, and/or arthrocentesis are often required to treat pseudosepsis.
Musculoskeletal side effects have included calf cramps, ankle edema, muscle pain, low back sprain, and pseudosepsis.
Cardiovascular side effects have included tachyarrhythmia and phlebitis with varicosities.
Nervous system side effects have included anxiety and listlessness, dizziness, headache, shivering, and body pain.
Respiratory side effects have included respiratory difficulties.
Metabolic side effects have included one case report of pseudogout and one of acute gout in a patient with no prior episodes.
Hypersensitivity reactions have included one reported case of a suspected allergic reaction with fever, large effusion in the knee, and synovial eosinophilia.
Local reactions have included acute painful joint effusions after injection into the knee in 1% to 11% of patients.
More about Synvisc (hylan g-f 20)
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