Synvisc Side Effects

Please note - some side effects for Synvisc may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Synvisc - for the Consumer

Synvisc Solution

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Synvisc Solution:

Knee pain or swelling after injection.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); ankle swelling; bruising; calf cramping; fast heartbeat; fever; hemorrhoids; muscle pain; nausea; persistent pain, redness, or swelling at injection site; sweating.

Side Effects by Body System

General

A retrospective study reported pain, warmth, and swelling after 11% of injections, in some cases lasting up to 3 weeks.

In clinical trials with 511 patients who received a total of 1771 injections, knee pain and/or swelling were reported in 7.2% patients or 2.2% of injections and were the most common adverse reactions.

Dermatologic

Dermatologic side effects have included individual cases of rash, itching, generalized urticaria, recurring small hives, facial flush with lip swelling, and body prickling. These symptoms did not reoccur upon rechallenge.

Gastrointestinal

Gastrointestinal side effects have included nausea and hemorrhoids.

Musculoskeletal

Pseudosepsis has been characterized as severe joint inflammation with pain and effusion occurring 24 to 72 hours after injection and it may be more likely to occur after the second or third injection or with repeated courses. Nonsteroidal anti-inflammatory drugs, intra-articular steroids, and/or arthrocentesis are often required to treat pseudosepsis.

Musculoskeletal side effects have included calf cramps, ankle edema, muscle pain, low back sprain, and pseudosepsis.

Cardiovascular

Cardiovascular side effects have included tachyarrhythmia and phlebitis with varicosities.

Nervous system

Nervous system side effects have included anxiety and listlessness, dizziness, headache, shivering, and body pain.

Respiratory

Respiratory side effects have included respiratory difficulties.

Metabolic

Metabolic side effects have included one case report of pseudogout and one of acute gout in a patient with no prior episodes.

Hypersensitivity

Hypersensitivity reactions have included one reported case of a suspected allergic reaction with fever, large effusion in the knee, and synovial eosinophilia.

Local

Local reactions have included acute painful joint effusions after injection into the knee in 1% to 11% of patients.

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