Synvisc Side Effects

Generic Name: hylan g-f 20

Note: This document contains side effect information about hylan g-f 20. Some of the dosage forms listed on this page may not apply to the brand name Synvisc.

Some side effects of Synvisc may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to hylan g-f 20: injection injectable, injection solution

Along with its needed effects, hylan g-f 20 (the active ingredient contained in Synvisc) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking hylan g-f 20:

  • Difficulty breathing
  • hives
  • shortness of breath

Some side effects of hylan g-f 20 may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Knee pain
  • pain at the injection site
  • swelling of the knee
  • Calf cramps
  • dizziness
  • facial flushing with swelling of the lips
  • headache
  • infection of the joint
  • itching of the skin
  • muscle pain
  • nausea
  • pain on one side of the body with anxiety, nausea, and tiredness
  • rapid heartbeat
  • skin rash

For Healthcare Professionals

Applies to hylan g-f 20: intra-articular solution


A retrospective study reported pain, warmth, and swelling after 11% of injections, in some cases lasting up to 3 weeks.

In clinical trials with 511 patients who received a total of 1771 injections, knee pain and/or swelling were reported in 7.2% patients or 2.2% of injections and were the most common adverse reactions.


Dermatologic side effects have included individual cases of rash, itching, generalized urticaria, recurring small hives, facial flush with lip swelling, and body prickling. These symptoms did not reoccur upon rechallenge.


Gastrointestinal side effects have included nausea and hemorrhoids.


Pseudosepsis has been characterized as severe joint inflammation with pain and effusion occurring 24 to 72 hours after injection and it may be more likely to occur after the second or third injection or with repeated courses. Nonsteroidal anti-inflammatory drugs, intra-articular steroids, and/or arthrocentesis are often required to treat pseudosepsis.

Musculoskeletal side effects have included calf cramps, ankle edema, muscle pain, low back sprain, and pseudosepsis.


Cardiovascular side effects have included tachyarrhythmia and phlebitis with varicosities.

Nervous system

Nervous system side effects have included anxiety and listlessness, dizziness, headache, shivering, and body pain.


Respiratory side effects have included respiratory difficulties.


Metabolic side effects have included one case report of pseudogout and one of acute gout in a patient with no prior episodes.


Hypersensitivity reactions have included one reported case of a suspected allergic reaction with fever, large effusion in the knee, and synovial eosinophilia.


Local reactions have included acute painful joint effusions after injection into the knee in 1% to 11% of patients.

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