Synvisc-One Side Effects

Generic name: hylan g-f 20

Medically reviewed by Drugs.com. Last updated on Jun 4, 2023.

Note: This document contains side effect information about hylan g-f 20. Some dosage forms listed on this page may not apply to the brand name Synvisc-One.

Applies to hylan g-f 20: injection injectable, injection solution. Other dosage forms:

• solution

Serious side effects of Synvisc-One

Along with its needed effects, hylan g-f 20 (the active ingredient contained in Synvisc-One) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking hylan g-f 20:

Rare

• Difficulty breathing
• hives
• shortness of breath

Other side effects of Synvisc-One

Some side effects of hylan g-f 20 may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Knee pain
• pain at the injection site
• swelling of the knee

Rare

• Calf cramps
• dizziness
• facial flushing with swelling of the lips
• headache
• infection of the joint
• itching of the skin
• muscle pain
• nausea
• pain on one side of the body with anxiety, nausea, and tiredness
• rapid heartbeat
• skin rash

For Healthcare Professionals

Applies to hylan g-f 20: intra-articular solution.

Dermatologic

Frequency not reported: Rash, itching, hives, itching, face swelling, generalized urticaria^[Ref]

Gastrointestinal

Frequency not reported: Hemorrhoids, nausea, tonsillitis^[Ref]

Musculoskeletal

Frequency not reported: Low back sprain, calf cramps, muscle cramps

Postmarketing reports: Acute inflammation (e.g., joint pain, swelling, effusion, joint warmth and/or stiffness)^[Ref]

Cardiovascular

Frequency not reported: Tachyarrhythmia, phlebitis with varicosities, flushing^[Ref]

Nervous system

Frequency not reported: Headache, dizziness, chills, paresthesia^[Ref]

Respiratory

Frequency not reported: Respiratory difficulty^[Ref]

Hypersensitivity

Frequency not reported: Synovial eosinophilia^[Ref]

Local

Postmarketing reports: Injection site pain, injection site swelling^[Ref]

Hematologic

Rare (less than 0.1%): Thrombocytopenia^[Ref]

Other

Frequency not reported: Ankle edema, fever, peripheral edema, malaise^[Ref]

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer