Synalar Mild Side Effects

Please note - some side effects for Synalar Mild may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects by Body System - for Healthcare Professionals

Applies to: compounding powder; topical cream; topical kit; topical lotion; topical oil; topical ointment; topical shampoo; topical solution

Local

Local side effects of fluocinolone have commonly included burning, itching, or irritation, especially when applied to denuded skin. Long-term use of topical corticosteroids has resulted in skin atrophy and thinning, and the development of striae, telangiectasia, subcutaneous hemorrhage, and easy bruising and bleeding. Allergic contact dermatitis has been occasionally reported.

Skin atrophy may become evident within one to two months of use and is due to the inhibitory effect of corticosteroids on collagen formation. Skin on the face, axillae, and groin appear to be most susceptible to the adverse, long-term effects of topical fluocinolone. Use of high potency topical corticosteroids on these areas should be minimized or avoided.

Topical corticosteroid use may inhibit local immune response rendering the skin more susceptible to infections. Folliculitis has occasionally been reported.

Perioral dermatitis or rosacea-like dermatitis has occurred in patients treated with potent topical corticosteroids who are of seborrheic skin type. This condition may flare temporarily upon discontinuation of topical steroids, prompting patients to continue their use. If topical corticosteroids are discontinued, this flare and the initial dermatitis generally resolves over a few weeks.

Endocrine

Endocrine side effects have included the rare suppression the hypothalamic-pituitary-adrenal axis. This suppression has been more likely when higher potency topical corticosteroids were used over extensive areas and when occlusive dressings were used.

Ocular

Ocular side effects have included the development of glaucoma in a young male who applied the steroid to his eyelids for a period of several years.

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