Symlin Side Effects

Generic Name: pramlintide

Note: This page contains side effects data for the generic drug pramlintide. It is possible that some of the dosage forms included below may not apply to the brand name Symlin.

It is possible that some side effects of Symlin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to pramlintide: subcutaneous solution

As well as its needed effects, pramlintide (the active ingredient contained in Symlin) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking pramlintide, check with your doctor immediately:

More common
  • Anxiety
  • blurred vision
  • chills
  • cold sweats
  • coma
  • confusion
  • cool pale skin
  • cough
  • depression
  • difficulty swallowing
  • dizziness
  • fast heartbeat
  • headache
  • hives
  • increased hunger
  • itching
  • nausea
  • nervousness
  • nightmares
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • seizures
  • shakiness
  • shortness of breath
  • skin rash
  • slurred speech
  • tightness in the chest
  • unusual tiredness or weakness
  • wheezing

Some pramlintide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Difficulty with moving
  • inflicted injury
  • loss of appetite
  • muscle pain or stiffness
  • pain in the joints
  • stomach pain
  • vomiting
  • weight loss
Less common
  • Body aches or pain
  • congestion
  • dryness or soreness of the throat
  • fever
  • hoarseness
  • runny nose
  • tender, swollen glands in the neck
  • trouble in swallowing
  • voice changes

For Healthcare Professionals

Applies to pramlintide: subcutaneous solution

Metabolic

Very common (10% or more): Severe hypoglycemia (up to 16.8%), anorexia (up to 17%)[Ref]

Gastrointestinal

Very common (10% or more): Nausea (up to 48%), vomiting (up to 11%)
Common (1% to 10%): Abdominal pain
Frequency not reported: Slower gastric emptying
Postmarketing reports: Pancreatitis[Ref]

Hypersensitivity

Common (1% to 10%): Allergic reaction[Ref]

Nervous system

Very common (10% or more): Headache
Common (1% to 10%): Dizziness[Ref]

Musculoskeletal

Common (1% to 10%): Arthralgia[Ref]

Respiratory

Common (1% to 10%): Cough, pharyngitis[Ref]

General

The most commonly reported side effects were: nausea, vomiting, and severe hypoglycemia.[Ref]

Local

Postmarketing reports: Injection site reactions[Ref]

Other

Very common (10% or more): Inflicted injury (14%)
Common (1% to 10%): Fatigue[Ref]

References

1. "Product Information. Symlin (pramlintide)." Amphastar Pharmaceuticals Inc, South El Monte, CA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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