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Surfaxin Side Effects

Generic Name: lucinactant

Note: This page contains side effects data for the generic drug lucinactant. It is possible that some of the dosage forms included below may not apply to the brand name Surfaxin.

For the Consumer

Applies to lucinactant: intratracheal suspension

As well as its needed effects, lucinactant (the active ingredient contained in Surfaxin) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking lucinactant, check with your doctor or nurse immediately:

More common
  • Bluish lips or skin
  • cough
  • coughing up blood
  • fast heartbeat
  • fever or chills
  • pale skin
  • rapid, shallow breathing
  • shortness of breath
  • slow heartbeat
  • sneezing
  • troubled breathing
  • wheezing
Incidence not known
  • Blue or white in color
  • heart may stop
  • no oxygen to lungs
  • patient unresponsive

Some lucinactant side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • clay-colored stools
  • coma
  • convulsions
  • dark urine
  • decreased urine output
  • fruit-like breath odor
  • loss of appetite
  • rapid, deep breathing
  • rash
  • restlessness
  • sweating
  • swelling of the face, ankles, or hands
  • unusual bleeding or bruising
  • vomiting of blood
  • yellow eyes or skin

For Healthcare Professionals

Applies to lucinactant: intratracheal suspension


Cardiovascular side effects have included patent ductus arteriosus (43%), hypotension (at least 10%) and bradycardia (at least 10%).[Ref]


Gastrointestinal side effects have included necrotizing enterocolitis (13%).[Ref]


General side effects have included pallor (up to 10%).[Ref]


Hematologic side effects have included anemia (at least 10%).[Ref]


Hepatic side effects have included jaundice (at least 10%).


Immunologic side effects have included acquired sepsis (up to 45%).[Ref]


Metabolic side effects have included metabolic acidosis (at least 10%), oxygen desaturation (at least 10%), hyperglycemia (at least 10%), hyponatremia (at least 10%), and respiratory acidosis (at least 10%).[Ref]

Nervous system

Nervous system side effects have included intraventricular hemorrhage (up to 52%), and periventricular leukomalacia (up to 10%).[Ref]


Ocular side effects have included retinopathy of prematurity (up to 32%).[Ref]


Respiratory side effects have included apnea (up to 66%), endotracheal tube reflux (up to 27%), pulmonary air leak (up to 15%), pneumonia (at least 10%), pulmonary hemorrhage (up to 10%), and endotracheal tube obstruction (up to 6%).[Ref]


1. "Product Information. Surfaxin (lucinactant)." Discovery Laboratories Inc, Warrington, PA.

It is possible that some side effects of Surfaxin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.