Sodium biphosphate / sodium phosphate Side Effects
For the Consumer
Applies to sodium biphosphate / sodium phosphate: oral liquid, oral solution, oral tablet
As well as its needed effects, sodium biphosphate / sodium phosphate may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking sodium biphosphate / sodium phosphate, check with your doctor immediately:More common
- Abdominal or stomach pain
- bloody or cloudy urine
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- decreased urine output
- difficult or labored breathing
- difficult or painful urination
- difficulty with swallowing
- fast, slow, or irregular heartbeat
- muscle twitching
- noisy breathing
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid weight gain
- redness of the skin
- skin rash, hives or welts, or itching
- swelling of the face, ankles, or hands
- tightness in the chest
- unusual tiredness or weakness
If any of the following symptoms of overdose occur while taking sodium biphosphate / sodium phosphate, get emergency help immediately:Symptoms of overdose
- Abdominal or stomach cramps
- blurred vision
- chest pain or discomfort
- decreased frequency of urine
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- dry mouth
- increase in heart rate
- increased thirst
- loss of appetite
- lower back or side pain
- muscle cramps in the hands, arms, feet, legs, or face
- muscle pain
- pounding or rapid pulse
- rapid breathing
- sunken eyes
- weight gain
- wrinkled skin
For Healthcare Professionals
Applies to sodium biphosphate / sodium phosphate: oral solution, oral tablet, rectal enema
Gastrointestinal side effects associated with sodium biphosphate-sodium phosphate tablets have included bloating (up to 47%), nausea (up to 37%), abdominal pain (up to 30%), and vomiting (up to 10%). Anal irritation, diarrhea, nausea, and stomach cramps have been reported with the enema formulation. Possible side effects associated with the enema formulation have included vomiting, abdominal pain, abdominal distension, gastrointestinal pain, and anal discomfort.[Ref]
Metabolic side effects associated with sodium biphosphate-sodium phosphate tablets have included changes in serum electrolytes (including phosphate, calcium, potassium, and sodium). Possible side effects associated with the enema formulation have included dehydration, hyperphosphatemia, hypocalcemia, hypernatremia, and metabolic acidosis.
Renal side effects associated with sodium biphosphate-sodium phosphate tablets have included renal impairment, increased blood urea nitrogen (BUN), increased creatinine, acute renal failure, acute phosphate nephropathy, nephrocalcinosis, and renal tubular necrosis during postmarketing experience.[Ref]
Nervous system side effects have included dizziness and headache. Seizures have been reported during postmarketing experience.[Ref]
Cardiovascular side effects associated with sodium biphosphate-sodium phosphate tablets have included arrhythmias during postmarketing experience.
Hypersensitivity side effects associated with sodium biphosphate-sodium phosphate tablets have included anaphylaxis, rash, pruritus, urticaria, throat tightness, bronchospasm, dyspnea, pharyngeal edema, dysphasia, paresthesia, swelling of the lips and tongue, and facial swelling during postmarketing experience. Possible side effects associated with the enema formulation have included hypersensitivity and pruritus.[Ref]
Respiratory side effects associated with sodium biphosphate-sodium phosphate tablets have included bronchospasm, dyspnea, and dysphagia during postmarketing experience; these side effects were associated with hypersensitivity reactions.
Other possible side effects associated with the enema formulation have included chills, blistering, and stinging.
1. Chan AT, Giovannucci EL, Meyerhardt JA, Schernhammer ES, Wu K, Fuchs CS "Aspirin dose and duration of use and risk of colorectal cncer in men." Gastroenterology 134 (2007): 21-8
It is possible that some side effects of sodium biphosphate / sodium phosphate may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
More about sodium biphosphate/sodium phosphate
- Sodium biphosphate and sodium phosphate
- Sodium biphosphate and sodium phosphate rectal
- Sodium phosphate dibasic and sodium phosphate monobasic (Advanced Reading)
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