Skyla Side Effects
Generic Name: levonorgestrel
Note: This page contains side effects data for the generic drug levonorgestrel. It is possible that some of the dosage forms included below may not apply to the brand name Skyla.
It is possible that some side effects of Skyla may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to levonorgestrel: oral tablet
Other dosage forms:
As well as its needed effects, levonorgestrel (the active ingredient contained in Skyla) may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking levonorgestrel, check with your doctor immediately:More common
- Heavy or light menstrual bleeding
- Absent missed or irregular menstrual periods
- irregular menstruation
- pain in the pelvis
- stopping of menstrual bleeding
Some levonorgestrel side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common
- Abdominal or stomach pain
- tenderness of the breasts
- unusual tiredness or weakness
For Healthcare Professionals
Applies to levonorgestrel: intrauteral device, oral tablet, subcutaneous implant
Cardiovascular side effects have included hypertension.[Ref]
Dermatologic side effects have included acne and other skin disorders.[Ref]
Gastrointestinal side effects have included abdominal pain, nausea, vomiting and diarrhea.[Ref]
Genitourinary side effects have included leukorrhea, vaginitis, dysmenorrhea, breast pain, abnormal pap smear and decreased libido. Very common adverse reactions (greater than 1 in 10 users) include uterine/vaginal bleeding (including spotting, irregular bleeding, heavy bleeding, oligomenorrhea and amenorrhea) and ovarian cysts.[Ref]
Nervous system side effects have included headache, dizziness and nervousness.[Ref]
Respiratory side effects have included upper respiratory infection and sinusitis.[Ref]
General side effects have included weight gain and fatigue.[Ref]
Psychiatric side effects have included depression.[Ref]
Musculoskeletal side effects have included back pain.[Ref]
Other side effects have included postmarketing reports of device breakage and angioedema.
1. "Product Information. Mirena (levonorgestrel)." Berlex Laboratories, Richmond, CA.
2. "Product Information. Plan B (levonorgestrel)." Women's Capital Corporation, Bellevue, WA.
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