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Sirturo Side Effects

Generic Name: bedaquiline

Note: This page contains side effects data for the generic drug bedaquiline. It is possible that some of the dosage forms included below may not apply to the brand name Sirturo.

It is possible that some side effects of Sirturo may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to bedaquiline: oral tablet

As well as its needed effects, bedaquiline (the active ingredient contained in Sirturo) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking bedaquiline, check with your doctor immediately:

More common
  • Abdominal or stomach pain or tenderness
  • chest pain
  • coughing or spitting up blood
  • dark-colored urine
  • decreased appetite
  • fever
  • general feeling of tiredness or weakness
  • headache
  • itching
  • light-colored stools
  • loss of appetite
  • nausea and vomiting
  • skin rash
  • swelling of the feet or lower legs
  • unusual tiredness or weakness
  • yellow eyes or skin
Incidence not known
  • Fainting
  • irregular heartbeat recurrent

Some bedaquiline side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Difficulty with moving
  • muscle pain or stiffness
  • pain in the joints

For Healthcare Professionals

Applies to bedaquiline: oral tablet


Very common (10% or more): Increased mortality risk/death (up to 12.7%), chest pain (up to 11%)[Ref]


Common (1% to 10%): QT prolongation[Ref]


Very common (10% or more): Elevated aminotransferases at least 3 times ULN (up to 10.8%)
Common (1% to 10%): Hepatotoxicity (increased ALT, increase AST, increased hepatic enzyme, abnormal hepatic function)[Ref]


Very common (10% or more): Nausea (up to 38%), vomiting (up to 20.6%)
Common (1% to 10%): Diarrhea, increased blood amylase[Ref]


Very common (10% or more): Arthralgia (up to 33%)
Common (1% to 10%): Myalgia[Ref]

Nervous system

Very common (10% or more): Headache (up to 28%), dizziness (up to 12.7%)[Ref]


Very common (10% or more): Hemoptysis (up to 18%)[Ref]


Common (1% to 10%): Anorexia[Ref]


Common (1% to 10%): Rash[Ref]


1. "Product Information. Sirturo (bedaquiline)." Janssen Pharmaceuticals, Titusville, NJ.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.