Medication Guide App

Signifor Side Effects

Generic Name: pasireotide

Note: This page contains side effects data for the generic drug pasireotide. It is possible that some of the dosage forms included below may not apply to the brand name Signifor.

It is possible that some side effects of Signifor may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to pasireotide: subcutaneous solution

As well as its needed effects, pasireotide (the active ingredient contained in Signifor) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking pasireotide, check with your doctor immediately:

More common
  • Abdominal or stomach pain or fullness
  • anxiety
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blurred vision
  • chills
  • cold sweats
  • coma
  • confusion
  • convulsions
  • cool, pale skin
  • darkening of the skin
  • decreased urine
  • depression
  • diarrhea
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • fainting
  • flushed, dry skin
  • fruit-like breath odor
  • gaseous abdominal or stomach pain
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • irregular heartbeat
  • loss of appetite
  • loss of consciousness
  • muscle pain or cramps
  • nausea or vomiting
  • nightmares
  • numbness or tingling in the hands, feet, or lips
  • pounding in the ears
  • rapid weight gain
  • recurrent fever
  • seizures
  • shakiness
  • shortness of breath
  • skin rash
  • slow or fast heartbeat
  • slurred speech
  • sweating
  • tingling of the hands or feet
  • troubled breathing
  • unexplained weight loss
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • yellow eyes or skin
Incidence not known
  • Clay-colored stools
  • constipation
  • darkened urine
  • dry skin and hair
  • feeling cold
  • fever
  • hair loss
  • hoarseness or husky voice
  • indigestion
  • itching
  • loss of appetite
  • muscle stiffness
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • unpleasant breath odor
  • vomiting of blood
  • weight gain

Some pasireotide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Back pain
  • bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • cough
  • decreased appetite
  • difficulty with moving
  • feeling of constant movement of self or surroundings
  • general feeling of discomfort or illness
  • joint pain
  • lack or loss of strength
  • pain in the arms or legs
  • pressure in the stomach
  • sensation of spinning
  • shivering
  • stuffy or runny nose
  • sweating
  • swelling of the abdominal or stomach area
  • swollen joints
  • trouble sleeping
  • upper abdominal or stomach pain

For Healthcare Professionals

Applies to pasireotide: subcutaneous solution

Cardiovascular

Very common (10% or more): Hypertension (10%)
Common (1% to 10%): Hypotension (7%), prolonged QT (6%), sinus bradycardia (6%)

Dermatologic

Very common (10% or more): Alopecia (12%)
Common (1% to 10%): Pruritus (8%), dry skin (6%)

Endocrine

Common (1% to 10%): Adrenal insufficiency (6%)

Gastrointestinal

Very common (10% or more): Diarrhea (58%), nausea (52%), abdominal pain (24%), upper abdominal pain (10%)
Common (1% to 10%): Constipation (7%), vomiting (7%), abdominal distention (6%)

General

Very common (10% or more): Asthenia (11%), peripheral edema (10%), decreased appetite (10%)

Hematologic

Very common (10% or more): Elevated PTT (47%), elevated PT (33%)
Common (1% to 10%): Anemia

Hepatic

Very common (10% or more): Cholelithiasis (30%), alanine aminotransferase increased (10%), gamma-glutamyl transferase increased (10%)
Common (1% to 10%): Aspartate aminotransferase increased (6%)

Local

Very common (10% or more): Injection site reactions (17%)

Metabolic

Very common (10% or more): Hyperglycemia (40%), diabetes mellitus (18%), glycosylated hemoglobin increased (11%), hypercholesterolemia (10%)
Common (1% to 10%): Hypoglycemia (9%), Type 2 diabetes mellitus (9%), lipase increased (7%), hypokalemia (6%), blood glucose increased (6%), blood amylase increased (2%)

Musculoskeletal

Common (1% to 10%): Myalgia (9%), arthralgia (8%), back pain (6%), pain in extremity (6%)

Nervous system

Very common (10% or more): Headache (28%), fatigue (19%)
Common (1% to 10%): Dizziness (9%), anxiety (9%), insomnia (9%), vertigo (6%)

Respiratory

Very common (10% or more): Nasopharyngitis (13%)
Common (1% to 10%): Influenza (9%)

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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