Medication Guide App

Sevoflurane Side Effects

It is possible that some side effects of sevoflurane may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to sevoflurane: inhalation liquid

As well as its needed effects, sevoflurane may cause unwanted side effects that require medical attention. While you are receiving and recovering from an inhalation anesthetic like sevoflurane, your health care professional will closely follow its effects. However, some effects may not be noticed until later.

Some sevoflurane side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Cough
  • dizziness
  • drowsiness
  • increased amount of saliva
  • nausea
  • shivering
  • vomiting
Less common
  • Headache

For Healthcare Professionals

Applies to sevoflurane: inhalation liquid

General

The most common adverse events were nausea, vomiting, hypotension, agitation, and cough.

Gastrointestinal

Very common (10% or more): Nausea (25%), vomiting (18%)
Common (1% to 10%): Increased salivation
Uncommon (0.1% to 1%): Dry mouth

Cardiovascular

Very common (10% or more): Hypotension (11%), bradycardia
Common (1% to 10%): Tachycardia, hypertension
Uncommon (0.1% to 1%): Arrhythmia, ventricular extrasystoles, supraventricular extrasystoles, complete AV block, bigeminy, inverted T wave, atrial fibrillation, atrial arrhythmia, second degree AV block, S-T depressed, extrasystoles
Frequency not reported: QT prolongation, torsade de pointes
Postmarketing reports: Cardiac arrest

Respiratory

Very common (10% or more): Cough increased (11%),
Common (1% to 10%): Laryngospasm, airway obstruction, breath holding, apnea, respiratory disorder
Uncommon (0.1% to 1%): Sputum increased, hypoxia, wheezing, bronchospasm, hyperventilation, pharyngitis, hiccup, hypoventilation, dyspnea, stridor, hypoxia, asthma
Postmarketing reports: Pulmonary edema

Psychiatric

Very common (10% or more): Agitation (up to 15%)
Uncommon (0.1% to 1%): Crying, nervousness, confusion, insomnia, confusional state

Nervous system

Common (1% to 10%): Somnolence, dizziness, movement
Uncommon (0.1% to 1%): Syncope, hypertonia, taste perversion
Postmarketing reports: Seizures, dystonia

Other

Common (1% to 10%): Shivering, fever, hypothermia, headache, blood fluoride increased
Uncommon (0.1% to 1%): Asthenia, pain, fluorosis,
Rare (less than 0.1%): Malignant hyperthermia

Hematologic

Common (1% to 10%): White blood cell count abnormal
Uncommon (0.1% to 1%): Hemorrhage, leukocytosis, thrombocytopenia, leukopenia
Postmarketing reports: Transient elevations in white blood cell count

Hepatic

Common (1% to 10%): Liver function test abnormal
Uncommon (0.1% to 1%): Increases in AST, increases in ALT, bilirubinemia
Postmarketing reports: Hepatic dysfunction, hepatitis, jaundice, hepatic necrosis, hepatic failure, transient elevations in liver function tests

Metabolic

Common (1% to 10%): Blood glucose abnormal
Uncommon (0.1% to 1%): Increases in LDH, increases in alkaline phosphatase, hypophosphatemia, acidosis, hyperglycemia
Postmarketing reports: Transient elevations in glucose

Renal

Uncommon (0.1% to 1%): Increases in BUN, increases in creatinine, glycosuria, albuminuria,
Frequency not reported: Mild impairment of renal concentrating ability
Postmarketing reports: Acute renal failure

Ocular

Uncommon (0.1% to 1%): Amblyopia, conjunctivitis

Genitourinary

Uncommon (0.1% to 1%): Urination impaired, urine abnormality, urinary retention, oliguria

Dermatologic

Uncommon (0.1% to 1%): Pruritus, rash

Hypersensitivity

Postmarketing reports: Allergic reactions, urticaria, bronchospasm, anaphylactic or anaphylactoid reaction, hypersensitivity (including contact dermatitis, rash, dyspnea, wheezing, chest discomfort, swelling face, or anaphylactic reaction)

Musculoskeletal

Postmarketing reports: Muscle twitching

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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