Sevelamer Side Effects
It is possible that some side effects of sevelamer may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to sevelamer: oral capsule, oral powder for suspension, oral tablet
As well as its needed effects, sevelamer may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking sevelamer, check with your doctor immediately:Incidence not known
- Bloody, black, or tarry stools
- severe abdominal or stomach pain, cramping, or burning
- severe constipation
- severe vomiting
- trouble with breathing
- vomiting of material that looks like coffee grounds, severe and continuing
Some sevelamer side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common
- Acid or sour stomach
- excess air or gas in the stomach or intestines
- full feeling
- passing gas
- stomach discomfort or upset
- Itching skin
For Healthcare Professionals
Applies to sevelamer: oral capsule, oral powder for reconstitution, oral tablet
Cardiovascular side effects reported have included hypertension, hypotension, and thrombosis.
General side effects reported included the body as a whole with complaints of headache, infection, and pain.
Gastrointestinal side effects reported included vomiting (12% to 22%), nausea (7% to 20%), diarrhea (4% to 19%), dyspepsia (5% to 16%), abdominal pain (9%), flatulence (4% to 9%), constipation (2% to 8%) and worsening of existing constipation, and peritonitis (8%). Fecal impaction, abdominal pain, intestinal perforation, intestinal obstruction, and uncommon cases of ileus have been reported during postmarketing experience.
Respiratory side effects reported have included increase in coughing episodes (4%).
Metabolic side effects reported during a postmarketing study (n=18) have included decreases in bicarbonate levels not directly related to the use of sevelamer, but instead caused by the discontinuation of calcium salts.
Dermatologic side effects including pruritus and rash have been reported during postmarketing experience.
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