Serzone Side Effects
Generic Name: nefazodone
Note: This document contains side effect information about nefazodone. Some of the dosage forms listed on this page may not apply to the brand name Serzone.
Some side effects of Serzone may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to nefazodone: oral tablet
Along with its needed effects, nefazodone (the active ingredient contained in Serzone) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur while taking nefazodone:More common
- Blurred vision or other changes in vision
- clumsiness or unsteadiness
- lightheadedness or fainting
- ringing in the ears
- skin rash or itching
- Bladder pain
- bloody or cloudy
- cough or hoarseness
- excessive muscle tone
- eye pain
- feeling dizzy
- frequent urge to urinate
- itching of the vagina or genital area
- muscle stiffness
- muscle tension or tightness
- pain during sexual intercourse
- painful, burning, or difficult urination
- shortness of breath, tightness in chest, or wheezing
- stomach pain
- thick, white vaginal discharge with no odor or with a mild odor
- troubled breathing
- bleeding from the rectum
- bloody or black, tarry stools
- change in sexual desire or performance
- chest pain
- double vision
- dryness of eye
- ear pain
- fast heartbeat
- fever, chills, or sore throat
- hallucinations (seeing, hearing, or feeling things that are not there)
- increased sense of hearing
- increased sensitivity to sun
- irritation or soreness of mouth
- joint or muscle pain or stiffness
- kidney stones
- large pupils of eyes
- lower back, side, or stomach pain
- menstrual changes
- mood or mental changes
- nerve pain or twitching
- pelvic pain
- problems in speaking
- problems with urination
- prolonged, painful, inappropriate penile erection
- red or irritated eyes
- sensitivity of eyes to light
- swelling of face
- swollen glands
- talking, feeling, and acting with excitement and activity you cannot control
- unusual bleeding or bruising
- unusual feeling of well-being
- unusual tiredness or weakness
- vomiting of blood or material that looks like coffee grounds
- Blistering, peeling, or loosening of skin
- light-colored stools
- dark urine
- decreased urine output
- increased thirst
- lack of appetite
- large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- muscle pain or cramps
- muscle spasm or jerking of all extremities
- muscle stiffness
- pain, warmth, or burning in fingers, toes, and legs
- red skin lesions, often with a purple center
- sore throat
- sudden loss of consciousness
Some side effects of nefazodone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Abnormal dreams
- dryness of mouth
- flushing or feeling of warmth
- increased appetite
- increased cough
- memory problems
- swelling of arms or legs
- tingling, burning, or prickly sensations
- trouble in sleeping
- Breast pain
- generalized slowing of mental and physical activity
- increased thirst
- loss of strength or energy
- muscle weakness
- Unexpected or excess milk flow from breasts
- swelling of the breasts or breast soreness in males
For Healthcare Professionals
Applies to nefazodone: oral tablet
The manufacturer reports that during premarketing testing, two cases of seizures occurred. In the first case, a patient with a history of petit mal seizures experienced a petit mal seizure. In the second case a non- study participant took 2000 to 3000 mg of nefazodone (the active ingredient contained in Serzone) with methocarbamol and alcohol and experienced a convulsion. The characteristics of the convulsion were not documented.
Nearly all selective serotonin reuptake inhibitors, mixed serotonin/norepinephrine reuptake inhibitors, and tricyclic antidepressants cause sleep abnormalities to some extent. These antidepressants have marked dose-dependent effects on rapid eye movement (REM) sleep, causing reductions in the overall amount of REM sleep over the night and delays the first entry into REM sleep (increased REM sleep onset latency (ROL)), both in healthy subjects and depressed patients. The antidepressants that increase serotonin function appear to have the greatest effect on REM sleep. The reduction in REM sleep is greatest early in treatment, but gradually returns towards baseline during long-term therapy; however, ROL remains long. Following discontinuation of therapy the amount of REM sleep tends to rebound. Some of these drugs (i.e., bupropion, mirtazapine, nefazodone, trazodone, trimipramine) appear to have a modest or minimal effect on REM sleep.
Nervous system side effects are common and include somnolence in as many as 28% of treated patients. Dizziness, lightheadedness, sleep abnormalities, confusion, headache, fatigue, akathisia, and asthenia have also been reported. Activation of mania and seizures, and serotonin syndrome have occurred rarely.
Gastrointestinal side effects including nausea (up to 32% of patients treated with high doses) have been reported.
Nausea has not generally been associated with vomiting and tends to diminish with ongoing treatment.
Ocular side effects including blurred vision (9%), and abnormal vision (scotomata and visual trails) (7%) have been reported.
Hepatic side effects including cases of liver failure have been reported rarely but have sometimes been fatal.
Cardiovascular side effects including postural hypotension (1% to 5.1%) and angioedema have been reported.
Priapism has not been reported in association with nefazodone (the active ingredient contained in Serzone) therapy but has been associated with use of the related antidepressant trazodone.
Genitourinary side effects including impotence, urinary frequency, and urinary retention have been reported. One case of spontaneous ejaculation has also been reported.
Anticholinergic side effects including dry mouth, blurred vision, and constipation have been reported, although much less frequently than with many other antidepressants.
Other side effects including an increase in REM sleep (in contrast to the effects of most other antidepressants) have been reported.
Endocrine side effects including galactorrhea, gynecomastia, and increased prolactin levels have been reported.
Psychiatric side effects have included two cases of mania. A case of increased anxiety in a patient with panic disorder on low dose nefazodone (the active ingredient contained in Serzone) has also been reported.
Hypersensitivity side effects including anaphylactic reactions have been reported.
Dermatologic side effects including Stevens-Johnson syndrome have been reported.
Metabolic side effects including hyponatremia have been reported.
Hematologic side effects including thrombocytopenia have been reported.
More about Serzone (nefazodone)
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