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Serzone Side Effects

Generic Name: nefazodone

Note: This page contains side effects data for the generic drug nefazodone. It is possible that some of the dosage forms included below may not apply to the brand name Serzone.

It is possible that some side effects of Serzone may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to nefazodone: oral tablet

As well as its needed effects, nefazodone (the active ingredient contained in Serzone) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking nefazodone, check with your doctor or nurse as soon as possible:

More common
  • Blurred vision or other changes in vision
  • clumsiness or unsteadiness
  • lightheadedness or fainting
  • ringing in the ears
  • skin rash or itching
Less common
  • Bladder pain
  • bloody or cloudy
  • cough or hoarseness
  • diarrhea
  • excessive muscle tone
  • eye pain
  • feeling dizzy
  • frequent urge to urinate
  • itching of the vagina or genital area
  • muscle stiffness
  • muscle tension or tightness
  • nausea
  • pain during sexual intercourse
  • painful, burning, or difficult urination
  • shortness of breath, tightness in chest, or wheezing
  • stomach pain
  • thick, white vaginal discharge with no odor or with a mild odor
  • troubled breathing
  • Asthma
  • bleeding from the rectum
  • bloody or black, tarry stools
  • change in sexual desire or performance
  • chest pain
  • double vision
  • dryness of eye
  • ear pain
  • fainting
  • fast heartbeat
  • fever, chills, or sore throat
  • hallucinations (seeing, hearing, or feeling things that are not there)
  • hives
  • increased sense of hearing
  • increased sensitivity to sun
  • irritation or soreness of mouth
  • joint or muscle pain or stiffness
  • kidney stones
  • large pupils of eyes
  • lower back, side, or stomach pain
  • menstrual changes
  • mood or mental changes
  • nerve pain or twitching
  • pelvic pain
  • problems in speaking
  • problems with urination
  • prolonged, painful, inappropriate penile erection
  • red or irritated eyes
  • sensitivity of eyes to light
  • swelling of face
  • swollen glands
  • talking, feeling, and acting with excitement and activity you cannot control
  • unusual bleeding or bruising
  • unusual feeling of well-being
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds
Incidence not known
  • Blistering, peeling, or loosening of skin
  • light-colored stools
  • confusion
  • dark urine
  • decreased urine output
  • fever
  • increased thirst
  • itching
  • lack of appetite
  • large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • muscle pain or cramps
  • muscle spasm or jerking of all extremities
  • muscle stiffness
  • pain, warmth, or burning in fingers, toes, and legs
  • red skin lesions, often with a purple center
  • sore throat
  • sudden loss of consciousness
  • sweating
  • vomiting

Some nefazodone side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Abnormal dreams
  • agitation
  • confusion
  • constipation
  • diarrhea
  • dizziness
  • drowsiness
  • dryness of mouth
  • flushing or feeling of warmth
  • headache
  • heartburn
  • increased appetite
  • increased cough
  • memory problems
  • nausea
  • swelling of arms or legs
  • tingling, burning, or prickly sensations
  • tremor
  • trouble in sleeping
  • vomiting
Less common or rare
  • Breast pain
  • generalized slowing of mental and physical activity
  • increased thirst
  • loss of strength or energy
  • muscle weakness
Incidence not known
  • Unexpected or excess milk flow from breasts
  • swelling of the breasts or breast soreness in males

For Healthcare Professionals

Applies to nefazodone: oral tablet


The most commonly reported side effects were somnolence, dry mouth, nausea, dizziness, constipation, asthenia, lightheadedness, blurred vision, confusion, and abnormal vision.[Ref]


Uncommon (0.1% to 1%): Abnormal liver function tests, increased SGOT, increased SGPT
Postmarketing reports: Liver necrosis, liver failure (in some cases leading to liver transplantation and/or death)[Ref]


Very common (10% or more): Insomnia
Uncommon (0.1% to 1%): Depersonalization, hallucinations, suicide attempt, suicidal thoughts, derealization, paranoid reaction, suicide[Ref]

Nervous system

Very common (10% or more): Headache (36%), somnolence (up to 28%), dizziness (up to 22%), lightheadedness (10%)
Common (1% to 10%): Confusion, memory impairment, paraesthesia, decreased concentration, ataxia, incoordination, psychomotor retardation, tremor, hypertonia, tinnitus, taste perversion
Uncommon (0.1% to 1%): Vertigo, twitching, apathy, euphoria, hostility, abnormal thinking, decreased attention, abnormal gait, neuralgia, dysarthria, myoclonus
Rare (less than 0.1%): Hyperkinesia, increased salivation, cerebrovascular accident, hyperesthesia, hypotonia, ptosis, neuroleptic malignant syndrome
Postmarketing reports: Convulsions (including grand mal seizures), serotonin syndrome[Ref]


Very common (10% or more): Dry mouth (25%), nausea (up to 23%), constipation (up to 17%)
Common (1% to 10%): Dyspepsia, diarrhea, vomiting, gastroenteritis
Uncommon (0.1% to 1%): Enlarged abdomen, halitosis, eructation, periodontal abscess, gingivitis, colitis, gastritis, mouth ulceration, stomatitis, esophagitis, peptic ulcer, rectal hemorrhage
Rare (less than 0.1%): Glossitis, hepatitis, dysphagia, gastrointestinal hemorrhage, oral moniliasis, ulcerative colitis[Ref]


Very common (10% or more): Abnormal vision
Common (1% to 10%): Blurred vision, visual field defect, eye pain
Uncommon (0.1% to 1%): Dry eye, abnormality of accommodation, diplopia, conjunctivitis, mydriasis, keratoconjunctivitis, hyperacusis, photophobia
Rare (less than 0.1%): Angle-closure glaucoma, night blindness[Ref]


Common (1% to 10%): Postural hypotension, hypotension, vasodilatation
Uncommon (0.1% to 1%): Tachycardia, hypertension, syncope, ventricular extrasystoles, angina pectoris
Rare (less than 0.1%): AV block, congestive heart failure, hemorrhage, pallor, varicose veins[Ref]


Common (1% to 10%): Decreased libido, urinary frequency, urinary tract infection, urinary retention, vaginitis, breast pain, impotence
Uncommon (0.1% to 1%): Pelvic pain, increased libido, cystitis, urinary urgency, metrorrhagia, amenorrhea, polyuria, vaginal hemorrhage, breast enlargement, menorrhagia, urinary incontinence, abnormal ejaculation, hematuria, nocturia
Rare (less than 0.1%): Enlarged uterine fibroids, uterine hemorrhage, anorgasmia, oliguria
Postmarketing reports: Priapism[Ref]


Very common (10% or more): Asthenia (11%)
Common (1% to 10%): Chills, fever, peripheral edema
Uncommon (0.1% to 1%): Malaise, face edema, hangover effect, hernia, increased lactic dehydrogenase, ear pain[Ref]


Postmarketing reports: Galactorrhea, gynecomastia (male), increased prolactin[Ref]


Uncommon (0.1% to 1%): Allergic reaction
Postmarketing reports: Anaphylactic reactions, angioedema, Stevens-Johnson syndrome[Ref]


Common (1% to 10%): Pruritus, rash
Uncommon (0.1% to 1%): Photosensitivity reaction, dry skin, acne, alopecia, urticaria, maculopapular rash, vesiculobullous rash, eczema[Ref]


Common (1% to 10%): Increased appetite, thirst
Uncommon (0.1% to 1%): Weight loss, gout, dehydration
Rare (less than 0.1%): Hypercholesteremia, hypoglycemia
Postmarketing reports: Hyponatremia[Ref]


Uncommon (0.1 to 1%): Ecchymosis, anemia, leukopenia, lymphadenopathy
Postmarketing reports: Thrombocytopenia[Ref]


Common (1% to 10%): Infection, flu syndrome
Rare (less than 0.1%): Cellulitis[Ref]


Common (1% to 10%): Neck rigidity, arthralgia
Uncommon (0.1% to 1%): Arthritis, tenosynovitis, muscle stiffness, bursitis
Rare (less than 0.1%): Tendinous contracture
Postmarketing reports: Rhabdomyolysis ( in patients receiving the combination of nefazodone (the active ingredient contained in Serzone) and lovastatin or simvastatin)[Ref]


Common (1% to 10%): Pharyngitis, increased cough, dyspnea, bronchitis
Uncommon (0.1% to 1%): Asthma, pneumonia, laryngitis, voice alteration, epistaxis, hiccup
Rare (less than 0.1%): Hyperventilation, yawn[Ref]


Uncommon (0.1% to 1%): Kidney calculus[Ref]


1. "Product Information. Serzone (nefazodone)." Bristol-Myers Squibb, Princeton, NJ.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.