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Seconal Sodium Side Effects

Generic Name: secobarbital

Please note - some side effects for Seconal Sodium may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Seconal Sodium Side Effects - for the Professional

Seconal Sodium

The following adverse reactions and their incidences were compiled from surveillance of thousands of hospitalized patients who received barbiturates. Because such patients may be less aware of some of the milder adverse effects of barbiturates, the incidence of these reactions may be somewhat higher in fully ambulatory patients.

More than 1 in 100 Patients

The most common adverse reaction estimated to occur at a rate of 1 to 3 patients per 100 is the following:

Nervous System: Somnolence

Less than 1 in 100 Patients

Adverse reactions estimated to occur at a rate of less than 1 in 100 patients are listed below, grouped by organ system and by decreasing order of occurrence:

Nervous System: Agitation, confusion, hyperkinesia, ataxia, CNS depression, nightmares, nervousness, psychiatric disturbance, hallucinations, insomnia, anxiety, dizziness, abnormality in thinking

Respiratory System: Hypoventilation, apnea

Cardiovascular System: Bradycardia, hypotension, syncope

Digestive System: Nausea, vomiting, constipation

Other Reported Reactions: Headache, injection site reactions, hypersensitivity reactions (angioedema, skin rashes, exfoliative dermatitis), fever, liver damage, megaloblastic anemia following chronic phenobarbital use

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Side Effects by Body System - for Healthcare Professionals

Nervous system

Nervous system side effects have included somnolence, headache, confusion, hyperkinesias, ataxia, and dizziness.

Cardiovascular

Cardiovascular side effects have included bradycardia, hypotension, and syncope.

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, and constipation.

Hypersensitivity

Hypersensitivity reactions have included angioedema, skin rash, and exfoliative dermatitis.

Oncologic

Oncologic side effects have included a possible increased frequency of malignancy (particularly liver cancer and brain tumors) following use of phenobarbital and other barbiturates.

Other

Other side effects have included physical and psychological dependence. Withdrawal symptoms have been reported when secobarbital therapy has been discontinued suddenly.

Psychiatric

Psychiatric side effects have included agitation, nightmares, nervousness, psychiatric disturbance, hallucinations, insomnia, anxiety, and abnormal thinking.

Respiratory

Respiratory side effects have included hypoventilation and apnea.

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