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Santyl Side Effects

Generic Name: collagenase topical

Note: This page contains side effects data for the generic drug collagenase topical. It is possible that some of the dosage forms included below may not apply to the brand name Santyl.

It is possible that some side effects of Santyl may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to collagenase topical: topical ointment

Side effects include:

Slight erythema.

For Healthcare Professionals

Applies to collagenase topical: compounding powder, topical ointment


The most commonly reported side effect was erythema.[Ref]


Frequency not reported: Systemic manifestations of hypersensitivity (in a patient treated for more than one year with a combination of collagenase and cortisone)[Ref]


Frequency not reported: Erythema[Ref]


1. "Product Information. Santyl (collagenase topical)." Knoll Pharmaceutical Company, Mount Olive, NJ.

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