Sancuso Side Effects
Generic Name: granisetron
Note: This page contains side effects data for the generic drug granisetron. It is possible that some of the dosage forms included below may not apply to the brand name Sancuso.
It is possible that some side effects of Sancuso may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to granisetron: intravenous solution
Other dosage forms:
As well as its needed effects, granisetron (the active ingredient contained in Sancuso) may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking granisetron, check with your doctor or nurse immediately:Less common
- Blurred vision
- pounding in the ears
- slow or fast heartbeat
- Arm, back, or jaw pain
- chest pain or discomfort
- chest tightness or heaviness
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- irregular heartbeat
- shortness of breath
- skin rash, hives, and itching
Some granisetron side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common
- Abdominal or stomach pain
- difficulty having a bowel movement (stool)
- lack or loss of strength
- unusual tiredness or weakness
- sleepiness or unusual drowsiness
- sour stomach
- trouble with sleeping
- unusual taste in the mouth
For Healthcare Professionals
Applies to granisetron: intravenous solution, oral solution, oral tablet, transdermal film extended release
Nervous system side effects have been reported the most frequently. These have included headache (up to 15% to 52.2%), dizziness (5% to 26.1%), insomnia (5%), anxiety (2%), somnolence (1%), asthenia, agitation, and stimulation. Headache (0.7%) has been reported in patients using the granisetron (the active ingredient contained in Sancuso) transdermal system. One case compatible with, but not diagnostic of, extrapyramidal symptoms has been reported.
Granisetron-induced headache is generally mild. In clinical trials, headache typically resolved spontaneously or was relieved by analgesics.
Gastrointestinal side effects have included nausea (20%), constipation (3% to 50%), vomiting (12%), diarrhea (4% to 9%), abdominal pain (4% to 6%), dyspepsia (4% to 6%), flatulence, dry mouth, and taste disturbances. Constipation (5.4%) has been reported in patients using the granisetron (the active ingredient contained in Sancuso) transdermal system.
Constipation appears to be dose related. In dose-finding studies, constipation occurred in up to 50% of patients treated with single doses of granisetron 300 mcg/kg. If necessary, constipation may be alleviated by the use of laxatives.
Hepatic side effects have been reported rarely. These have included elevations in serum transaminases (two times normal values). Causality is unknown. Acute pancreatitis has also been reported.
Cardiovascular side effects have included hypertension in 1% of patients. Atrial fibrillation, angina pectoris, and syncope have been reported rarely. Hypotension, sinus bradycardia, A-V block, ventricular ectopy, QT prolongation, and ECG changes have been reported as well, although causality is unknown.
Results of a review of the cardiovascular effects of the drug class 5-hydroxytryptamine 3 receptor antagonists in the literature reported that electrocardiographic (ECG) changes were so small to be considered clinically insignificant. ECG changes were most noticeable between 1 to 2 hours after a dose of granisetron and returned to baseline within 24 hours. To date, no serious cardiac side effects (including torsades de pointes) triggered by ECG interval changes have been connected with the use of 5-HT 3 receptor antagonists.
Hypersensitivity side effects have been reported rarely. These have included skin rashes, facial flushing, anaphylactoid reactions, shortness of breath, hypotension, and urticaria. One report suggests hypersensitivity reactions with 5-HT 3-antagonists may be a class effect and cross-reactive.
Other side effects including asthenia (5% to 18%) and fever (up to 8%) have been reported.
More about Sancuso (granisetron)
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