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SAMe Side Effects

Generic Name: s-adenosylmethionine

Note: This page contains side effects data for the generic drug s-adenosylmethionine. It is possible that some of the dosage forms included below may not apply to the brand name SAMe.

It is possible that some side effects of SAMe may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Applies to s-adenosylmethionine: oral tablet

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Although not all side effects are known, SAMe is thought to be likely safe for most adults.

Common side effects may include:

  • headache, dizziness;

  • feeling anxious or nervous;

  • vomiting, upset stomach;

  • diarrhea, constipation;

  • increased sweating; or

  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

More about SAMe (s-adenosylmethionine)

Consumer resources

Professional resources

Related treatment guides

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