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S-Caine Peel Side Effects

Generic name: lidocaine / tetracaine topical

Medically reviewed by Drugs.com. Last updated on Jan 20, 2024.

Note: This document contains side effect information about lidocaine / tetracaine topical. Some dosage forms listed on this page may not apply to the brand name S-Caine Peel.

Applies to lidocaine/tetracaine topical: topical application cream, topical application patch extended release.

Serious side effects of S-Caine Peel

Along with its needed effects, lidocaine/tetracaine topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking lidocaine / tetracaine topical:

More common

Less common

Rare

Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking lidocaine / tetracaine topical:

Symptoms of overdose

Other side effects of S-Caine Peel

Some side effects of lidocaine / tetracaine topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare

Incidence not known

For Healthcare Professionals

Applies to lidocaine / tetracaine topical: topical cream, topical film.

Local

Local side effects have included erythema , blanching, edema, or abnormal sensation at the site of treatment. The most common of the local reactions were erythema (71%), blanching (12%), and edema (12%). These reactions were generally mild, and resolved spontaneously soon after treatment.[Ref]

Hypersensitivity

Hypersensitivity side effects have included allergic or anaphylactoid reactions to the active or inactive ingredients. They may be characterized by urticaria, angioedema, bronchospasm, and shock.[Ref]

Nervous system

Nervous system side effects are unlikely with appropriate use of lidocaine-tetracaine topical. Potential side effect include CNS excitation and/or depression (light-headedness, nervousness, apprehension, euphoria, confusion, dizziness, drowsiness, tinnitus, blurred or double vision, vomiting, sensations of heat, cold, or numbness, twitching, tremors, convulsions, unconsciousness, respiratory depression and arrest). Excitatory CNS reactions may be brief or not occur at all, in which case the first manifestation may be drowsiness developing into unconsciousness. Signs of CNS toxicity may start at plasma concentrations of lidocaine as low as 1000 ng/mL. The plasma concentrations at which tetracaine toxicity may occur are less well characterized; however, systemic toxicity with tetracaine is thought to occur with much lower plasma concentrations compared with lidocaine. The toxicity of co-administered local anesthetics is thought to be at least additive.[Ref]

Cardiovascular

Cardiovascular side effects are unlikely with appropriate use of lidocaine-tetracaine topical. Potential side effects include bradycardia, hypotension and cardiovascular collapse leading to arrest.[Ref]

More about S-Caine Peel (lidocaine / tetracaine topical)

Patient resources

Other brands

Pliaglis, Synera

Professional resources

Other brands

Pliaglis

Related treatment guides

References

1. Product Information. Synera (lidocaine-tetracaine topical). Ferndale Laboratories Inc. 2005.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.