Ruxolitinib Side Effects

It is possible that some side effects of ruxolitinib may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to ruxolitinib: oral tablet

As well as its needed effects, ruxolitinib may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking ruxolitinib, check with your doctor immediately:

More common
  • Black, tarry stools
  • bladder pain
  • bleeding gums
  • blood in the urine or stools
  • bruising
  • chills
  • cloudy urine
  • collection of blood under the skin
  • cough
  • deep, dark purple bruise
  • difficult, burning, or painful urination
  • fever
  • frequent urge to urinate
  • itching, pain, redness, or swelling
  • large, flat, blue or purplish patches in the skin
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • pus in the urine
  • shortness of breath
  • small, red or purple spots on the skin
  • sore throat
  • troubled breathing with exertion
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Less common
  • Painful blisters on the trunk of the body

Some ruxolitinib side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Bloated or full feeling
  • dizziness or lightheadedness
  • excess air or gas in the stomach or intestines
  • feeling of constant movement of self or surroundings
  • headache
  • passing gas
  • sensation of spinning
  • weight gain

For Healthcare Professionals

Applies to ruxolitinib: oral tablet

Dermatologic

Very common (10% or more): Bruising (up to 23.2%)
Common (1% to 10%): Herpes zoster

Gastrointestinal

Common (1% to 10%): Flatulence, gastrointestinal bleeding

Genitourinary

Very common (10% or more): Urinary tract infection (up to 14.4%)

Hematologic

Very common (10% or more): Anemia (up to 96.1%), thrombocytopenia (up to 69.8%), neutropenia (up to 18.7%)

Immunologic

Common (1% to 10%): Tuberculosis
Frequency not reported: Progressive multifocal leukoencephalopathy

Metabolic

Very common (10% or more): Hypercholesterolemia (up to 17.4%), weight gain (up to 10%)

Nervous system

Very common (10% or more): Dizziness (up to 18.1%), headache (up to 14.8%)
Common (1% to 10%): Intracranial bleeding

General

The most common adverse reactions were anemia, thrombocytopenia, bruising, dizziness, and headache.

Cardiovascular

Very common (10% or more): Bleeding (up to 32.6%)

Hepatic

Very common (10% or more): ALT increased (up to 27.1%), AST increased (up to 19.3%)

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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