Roxicodone Solution Side Effects
Please note - some side effects for Roxicodone Solution may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
Side Effects by Body System - for Healthcare Professionals
Applies to: compounding powder; oral capsule; oral concentrate; oral solution; oral tablet; oral tablet, extended release
In general, the adverse effects that occur with oxycodone are similar with the immediate- and controlled-release products. Adverse effects may be dose-related in opioid naive patients. Patients who are tolerant to the analgesic effect of oxycodone may be tolerant to the dose-related side effects, except constipation.
Nervous system side effects are common and include drowsiness (23% to 24%), sedation, dizziness (13% to 16%), headache (7%). dry mouth (7%), and lightheadedness. Many of the central nervous system adverse effects may be minimized by slow titration of the dose.
Respiratory depression may occur with any opioid, including oxycodone. Other effects may include apnea, respiratory arrest, and rarely circulatory collapse.
Severe adverse effects such as respiratory depression can be treated with the opioid antagonist naloxone. (The usual adult dose of naloxone is 1 to 2 mg every 5 minutes as necessary to a maximum of 10 mg. The dose can be administered intravenously, intramuscularly, subcutaneously, and sublingually.)
Nausea (23% to 27%), vomiting (12% to 14%), and constipation (23% to 26%) occur commonly. There have been rare reports of difficulty in swallowing the tablets, intestinal obstruction, and exacerbation of diverticulitis, some of which have required medical intervention to remove the tablet. Patients with underlying GI disorders such as esophageal cancer or colon cancer with a small gastrointestinal lumen are at greater risk of developing these complications.
Withdrawal symptoms, after either abrupt cessation or fast tapering of narcotic analgesics, may occur and include agitation, palpitations, restlessness, anxiety, insomnia, tremor, abdominal cramps, blurred vision, vomiting, piloerection, and sweating.
Psychosis has also been reported during withdrawal from oxycodone.
Psychiatric adverse effects reported include paranoia, psychosis, and hallucinations.
Pruritus has been reported rarely. Diphenhydramine (25 to 50 mg) has been shown to be helpful for opioid-associated pruritus.
Hepatic side effects including increased hepatic enzymes have been reported.
Cardiovascular side effects from higher doses have included QTc prolongation.Top
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