Roxicodone Side Effects

Generic Name: oxycodone

Note: This page contains side effects data for the generic drug oxycodone. It is possible that some of the dosage forms included below may not apply to the brand name Roxicodone.

It is possible that some side effects of Roxicodone may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to oxycodone: oral capsule, oral solution, oral tablet, oral tablet extended release

As well as its needed effects, oxycodone (the active ingredient contained in Roxicodone) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking oxycodone, check with your doctor immediately:

Less common
  • Chills
  • cold sweats
  • confusion
  • difficult or labored breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fever
  • tightness in the chest
  • twitching
Rare
  • Abdominal or stomach pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine
  • burning while urinating burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • convulsions
  • cough
  • decrease in the frequency of urination
  • decrease in urine volume
  • decreased urine output
  • difficult or painful urination
  • difficulty in passing urine (dribbling)
  • difficulty with swallowing
  • dizziness
  • dry mouth
  • fainting
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling of warmth or heat
  • flushing or redness of the skin, especially on the face and neck
  • frequent urination
  • headache
  • hives, itching, or skin rash
  • increase in heart rate
  • increased thirst
  • increased volume of pale, dilute urine
  • lightheadedness
  • muscle pain or cramps
  • nausea or vomiting
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid breathing
  • rapid weight gain
  • severe constipation
  • severe vomiting
  • shakiness in the legs, arms, hands, or feet
  • sunken eyes
  • sweating
  • swelling or puffiness of the face
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • thirst
  • tingling of the hands or feet
  • trembling or shaking of the hands or feet
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • wrinkled skin
Incidence not known
  • Blurred vision
  • choking
  • clay-colored stools
  • cold, clammy skin
  • dark urine
  • diarrhea
  • fast, weak pulse
  • gagging
  • irregular, fast, slow, or shallow breathing
  • loss of appetite
  • low blood pressure or pulse
  • pale or blue lips, fingernails, or skin
  • unconsciousness
  • unpleasant breath odor
  • very slow breathing
  • very slow heartbeat
  • yellow eyes or skin

If any of the following symptoms of overdose occur while taking oxycodone, get emergency help immediately:

Symptoms of overdose
  • Change in consciousness
  • chest pain or discomfort
  • constricted, pinpoint, or small pupils (black part of the eye)
  • decreased awareness or responsiveness
  • extreme drowsiness
  • loss of consciousness
  • no muscle tone or movement
  • severe sleepiness
  • slow or irregular heartbeat

Some oxycodone side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Difficulty having a bowel movement (stool)
  • drowsiness
  • lack or loss of strength
  • relaxed and calm feeling
  • sleepiness or unusual drowsiness
Less common
  • Abnormal dreams
  • acid or sour stomach
  • anxiety
  • belching
  • burning feeling in the chest or stomach
  • false or unusual sense of well-being
  • heartburn
  • hiccups
  • indigestion
  • stomach discomfort, upset, or pain
  • tenderness in the stomach area
  • trouble sleeping
  • weight loss
Rare
  • Absent, missed, or irregular menstrual periods
  • bad, unusual or unpleasant (after) taste
  • bloated or full feeling
  • body aches or pain
  • change in taste
  • change in walking and balance
  • changes in vision
  • clumsiness or unsteadiness
  • congestion
  • continuing ringing or buzzing or other unexplained noise in the ears
  • cracks in the skin
  • crying
  • decreased interest in sexual intercourse
  • dental caries or tooth decay
  • depersonalization
  • depression
  • difficulty with speaking
  • dry skin
  • dryness or soreness of the throat
  • dysphoria
  • excess air or gas in the stomach or intestines
  • excessive muscle tone
  • feeling of constant movement of self or surroundings
  • feeling of unreality
  • general feeling of discomfort or illness
  • headache, severe and throbbing
  • hearing loss
  • hoarseness
  • hyperventilation
  • inability to have or keep an erection
  • increase in body movements
  • increased appetite
  • increased cough
  • irritability
  • loss in sexual ability, desire, drive, or performance
  • loss of heat from the body
  • loss of memory
  • loss of strength or energy
  • mental depression
  • muscle pain or weakness
  • muscle stiffness
  • muscle tension or tightness
  • neck pain
  • paranoia
  • passing of gas
  • problems with memory
  • quick to react or overreact emotionally
  • rapidly changing moods
  • red, swollen skin
  • restlessness
  • runny nose
  • scaly skin
  • sensation of spinning
  • sense of detachment from self or body
  • severe sleepiness
  • stomach pain, fullness, or discomfort
  • stopping of menstrual bleeding
  • swelling or inflammation of the mouth
  • tender, swollen glands in the neck
  • unusual weak feeling
  • voice changes

For Healthcare Professionals

Applies to oxycodone: compounding powder, oral capsule, oral concentrate, oral solution, oral tablet, oral tablet extended release

Nervous system

Frequency not reported: Confusion, hypertonia, hypesthesia, nervousness, neuralgia, personality disorder, tremor, migraine[Ref]

Respiratory

Frequency not reported: Apnea, respiratory arrest, bronchitis, cough increased, dyspnea, epistaxis, laryngismus, lung disorder, pharyngitis, rhinitis, sinusitis[Ref]

Severe adverse effects such as respiratory depression can be treated with the opioid antagonist naloxone.[Ref]

Gastrointestinal

Very common (10% or more): Nausea (23% to 27%), constipation (23% to 26%), vomiting (12% to 14%)
Frequency not reported: Abdominal pain, anorexia, diarrhea, dyspepsia, dysphagia, gingivitis, glossitis[Ref]

Psychiatric

Frequency not reported: Paranoia, psychosis, hallucinations, agitation, anxiety[Ref]

Dermatologic

Rare (less than 0.1%): Pruritus
Frequency not reported: Herpes simplex, rash, sweating, urticaria[Ref]

Hepatic

Frequency not reported: Increased hepatic enzymes

Cardiovascular

Frequency not reported: QTc prolongation at higher doses, deep thrombophlebitis, heart failure, hemorrhage, hypotension, palpitation, tachycardia, edema, peripheral edema, vasodilation, circulatory collapse[Ref]

Genitourinary

Frequency not reported: Urinary tract infection[Ref]

Hypersensitivity

Frequency not reported: Allergic reaction

Immunologic

Frequency not reported: Flu syndrome, infection, sepsis[Ref]

Metabolic

Frequency not reported: Gout, hyperglycemia, iron deficiency anemia[Ref]

Musculoskeletal

Frequency not reported: Back pain, neck pain, arthralgia, arthritis, bone pain, myalgia, pathological fracture[Ref]

Ocular

Frequency not reported: Photosensitivity reaction, amblyopia[Ref]

Other

Frequency not reported: Chills and fever, accidental injury[Ref]

References

1. Glare P, Walsh D "Dose-ranging study of oxycodone for advanced cancer pain (meeting abstract)." Proc Annu Meet Am Soc Clin Oncol 10 (1991): a1201

2. Sunshine A, Olson NZ, Zighelboim I, Decastro A "Ketoprofen, acetaminophen plus oxycodone, and acetaminophen in the relief of postoperative pain." Clin Pharmacol Ther 54 (1993): 546-55

3. Leow KP, Smith MT, Watt JA, Williams BE, Cramond T "Comparative oxycodone pharmacokinetics in humans after intravenous, oral, and rectal administration." Ther Drug Monit 14 (1992): 479-84

4. Glare PA, Walsh TD "Dose-ranging study of oxycodone for chronic pain in advanced cancer." J Clin Oncol 11 (1993): 973-8

5. Leow KP, Smith MT, Williams B, Cramond T "Single-dose and steady-state pharmacokinetics and pharmacodynamics of oxycodone in patients with cancer." Clin Pharmacol Ther 52 (1992): 487-95

6. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

7. "Product Information. OxyContin (oxycodone)." Purdue Frederick Company, Norwalk, CT.

8. Fishbain DA, Goldberg M, Rosomoff RS, Rosomoff H "Atypical withdrawal syndrome (organic delusional syndrome) secondary to oxycodone detoxification ." J Clin Psychopharmacol 8 (1988): 441-2

9. Fanoe S, Jensen GB, Sjogren P, Korsgaard MP, Grunnet M "Oxycodone is associated with dose-dependent QTc prolongation in patients and low-affinity inhibiting of hERG activity in vitro." Br J Clin Pharmacol 67 (2008): 172-9

10. Gardos G "Dyskinesia after discountinuation of compound analgesic containing oxycodone ." Lancet 1 (1977): 759-60

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