Rimantadine Side Effects

Brand Names: Flumadine

Please note - some side effects for Rimantadine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Rimantadine - for the Consumer

Rimantadine

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Rimantadine:

Dizziness; dry mouth; headache; loss of appetite; nausea; nervousness; stomach pain; tiredness; trouble sleeping; vomiting; weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; depression; fast or irregular heartbeat; hallucinations; seizures; swelling of the hands, ankles, or feet; tremor; trouble walking.

Rimantadine Syrup

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Rimantadine Syrup:

Dizziness; dry mouth; headache; loss of appetite; nausea; nervousness; stomach pain; tiredness; trouble sleeping; vomiting; weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; depression; fast or irregular heartbeat; hallucinations; seizures; swelling of the hands, ankles, or feet; tremor; trouble walking.

Side Effects by Body System

General

Gastrointestinal and nervous system side effects are most frequently reported. In a prophylaxis trial, 6.9% of subjects discontinued treatment due to adverse reactions. In geriatric patients, gastrointestinal and nervous system adverse effects occurred twice as often with rimantadine than with placebo.

Nervous system

Seizures were reported in a few patients during clinical trials with rimantadine. In two patients, seizure activity had been absent for greater than 10 years. However, their anticonvulsant medications had been withdrawn in the previous few months.

Nervous system side effects have included dizziness, jitteriness, insomnia, headache, nervousness, and fatigue in 1% to 3% of patients. Ataxia, impairment of concentration, somnolence, agitation, and depression have been reported in 0.3% to 1% of patients. Gait abnormality, euphoria, hyperkinesia, tremor, hallucination, confusion, and convulsions have occurred in less than 0.3% of patients.

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, anorexia, dry mouth, and abdominal pain in 1% to 3% of patients. Diarrhea and dyspepsia have been reported in 0.3% to 1% of patients. Tolerance may be improved by giving the drug in two divided daily doses.

Cardiovascular

Cardiovascular side effects have included cardiac failure, cerebrovascular disorder, heart block, hypertension, pallor, palpitation, pedal edema, syncope, and tachycardia in less than 0.3% of patients.

Respiratory

Respiratory side effects have included dyspnea (0.3% to 0.1%), bronchospasm (<0.3%), and cough (<0.3%).

Other

Other side effects have included asthenia (1.4%), tinnitus (0.3% to 1%), taste loss/change (<0.3%), and parosmia (<0.3%).

Dermatologic

Dermatologic side effects have included rash in less than 1% of patients,

Endocrine

Endocrine side effects have included nonpuerperal lactation in less than 0.3% of patients.

Other

Increased lacrimation, increased micturition frequency, fever, rigors, agitation, constipation, diaphoresis, dysphagia, stomatitis, hypesthesia, and eye pain have occurred with higher than recommended doses of rimantadine.

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