Retin A Micro Side Effects

Generic Name: tretinoin topical

Note: This document contains side effect information about tretinoin topical. Some of the dosage forms listed on this page may not apply to the brand name Retin A Micro.

Some side effects of Retin A Micro may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to tretinoin topical: topical cream, topical gel/jelly, topical liquid, topical solution

In some animal studies, tretinoin has been shown to cause skin tumors to develop faster when the treated area is exposed to ultraviolet light (sunlight or artificial sunlight from a sunlamp). Other studies have not shown the same result and more studies need to be done. It is not known if tretinoin causes skin tumors to develop faster in humans.

Along with its needed effects, tretinoin topical (the active ingredient contained in Retin A Micro) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking tretinoin topical:

More common
  • Burning feeling or stinging skin (severe)
  • lightening of skin of treated area, unexpected
  • peeling of skin (severe)
  • redness of skin (severe)
  • unusual dryness of skin (severe)
Rare
  • Darkening of treated skin

Some side effects of tretinoin topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Burning feeling, stinging, or tingling of skin (mild)—lasting for a short time after first applying the medicine
  • chapping or slight peeling of skin (mild)
  • redness of skin (mild)
  • unusual dryness of skin (mild)
  • unusually warm skin (mild)

The side effects will go away after you stop using tretinoin. On the rare chance that your skin color changes, this effect may last for several months before your skin color returns to normal.

For Healthcare Professionals

Applies to tretinoin topical: topical cream, topical gel, topical kit, topical liquid

Dermatologic

A severe cutaneous reaction was reported in a patient who had an ice pack placed over an area treated with topical tretinoin. The area became pigmented and indurated, and the pigmentation persisted for an extensive length of time.

Dermatologic side effects are the most frequently reported side effects with the use of tretinoin topical. In double-blind, vehicle-controlled studies involving 339 patients who applied tretinoin topical 0.02% to their faces, adverse reactions associated with the use of tretinoin topical were limited primarily to the skin. Almost all patients reported one or more local reactions such as peeling, dry skin, burning, stinging, erythema, and pruritus. In 24% of all study patients, skin irritation was reported that was either severe (about 7%), led to temporary discontinuation of tretinoin topical 0.02% (about 20%), or led to use of a mild topical corticosteroid. About 5% of patients using tretinoin topical 0.02%, compared to less than 1% of the control patients, had sufficiently severe local irritation to warrant short-term use of mild topical corticosteroids to alleviate local irritation. About 4% of patients had to discontinue use of tretinoin topical because of adverse reactions. Tretinoin may induce photosensitivity in some individuals, as well as an increased susceptibility to irritation from wind, cold, and dryness.

Local

Local side effects including a retinoid dermatitis has been reported to occur frequently at the areas treated with topical tretinoin and is characterized by erythema, dryness, scaling, pruritus, and variable degrees of irritation.

Local reaction is commonly observed during the initial phase of therapy, but may not appear until as late as ten weeks into treatment. The dermatitis generally subsides with prolonged use of the medication, although in some cases may require a dosage adjustment or discontinuation of therapy. True contact dermatitis has been reported and confirmed with patch testing and leukocyte migration inhibition studies, but is uncommon. Rarely, there may be temporary hyper- or hypopigmentation following repeated applications.

Ocular

Ocular side effects including ectropions may develop infrequently and are reversible. A transient and harmless stinging of the eye may occur when tretinoin is applied onto the surrounding skin, generally lasting about 30 to 60 seconds.

Hepatic

Hepatic side effects including reversible, clinically insignificant changes in liver function tests have been reported following both oral and topical administration of tretinoin. These abnormalities include elevations in serum bilirubin, alkaline phosphatase, glutamic-oxaloacetic transaminase, and glutamic-pyruvic transaminase.

Nervous system

Nervous system side effects including a case of neurotoxicity in a patient with liver disease have been reported.

The patient developed neurological side effects following 4 weeks of tretinoin administration. Symptoms included headache, memory loss, truncal ataxia, and dysarthria, all of which improved upon temporary discontinuation of medication and recurred when the patient resumed usage. Upon withdrawal of medication a second time, the symptoms resolved within 4 weeks.

Genitourinary

Estrogen levels appeared not to have been affected.

Genitourinary side effects including an isolated case of vaginal bleeding related to tretinoin use has been reported in a post-menopausal woman and confirmed upon rechallenge.

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