Renvela Side Effects
Generic name: sevelamer
Note: This document contains side effect information about sevelamer. Some of the dosage forms listed on this page may not apply to the brand name Renvela.
Some side effects of Renvela may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to sevelamer: oral powder for reconstitution, oral tablet
Get emergency medical help if you have any of these signs of an allergic reaction while taking sevelamer (the active ingredient contained in Renvela) hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using sevelamer and call your doctor at once if you have a serious side effect such as:
black, bloody, or tarry stools;
constipation that gets worse or does not clear up;
severe constipation with stomach pain; or
fever, chills, body aches, flu symptoms.
Less serious side effects of sevelamer may include:
nausea, vomiting, stomach pain, loss of appetite;
upset stomach, gas, bloating;
diarrhea, mild constipation;
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to sevelamer: oral capsule, oral powder for reconstitution, oral tablet
Cardiovascular side effects reported have included hypertension, hypotension, and thrombosis.
General side effects reported included the body as a whole with complaints of headache, infection, and pain.
Gastrointestinal side effects reported included vomiting (12% to 22%), nausea (7% to 20%), diarrhea (4% to 19%), dyspepsia (5% to 16%), abdominal pain (9%), flatulence (4% to 9%), constipation (2% to 8%) and worsening of existing constipation, and peritonitis (8%). Fecal impaction, abdominal pain, intestinal perforation, intestinal obstruction, and uncommon cases of ileus have been reported during postmarketing experience.
Respiratory side effects reported have included increase in coughing episodes (4%).
Metabolic side effects reported during a postmarketing study (n=18) have included decreases in bicarbonate levels not directly related to the use of sevelamer (the active ingredient contained in Renvela) but instead caused by the discontinuation of calcium salts.
Dermatologic side effects including pruritus and rash have been reported during postmarketing experience.
More Renvela resources
- Renvela Prescribing Information (FDA)
- Renvela MedFacts Consumer Leaflet (Wolters Kluwer)
- Renvela Advanced Consumer (Micromedex) - Includes Dosage Information
- Renvela Consumer Overview
- Sevelamer Professional Patient Advice (Wolters Kluwer)
- Sevelamer Monograph (AHFS DI)
- Renagel Prescribing Information (FDA)
- Renagel Consumer Overview
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