Pyridoxine Side Effects
It is possible that some side effects of pyridoxine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to pyridoxine: capsule, injectable, solution, tablet, tablet enteric coated, tablet extended release
As well as its needed effects, pyridoxine may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking pyridoxine, check with your doctor or nurse as soon as possible:With large doses
- numbness of hands or feet
For Healthcare Professionals
Applies to pyridoxine: compounding powder, injectable solution, oral tablet
The profound sensory loss following treatment with high doses of parenteral pyridoxine may not be reversible.[Ref]
Nervous system side effects have included sensory neuropathy with axonal degeneration. The adverse neurologic side effects have been reported following a single large dose (10 g) administered intravenously. It may rarely occur following chronic administration of lower doses. Peripheral sensory neuropathy has also been reported.[Ref]
Hypersensitivity side effects have been reported rarely.[Ref]
Dermatologic side effects have included allergic contact dermatitis. Photosensitivity has been confirmed in a female patient taking pyridoxine 100 mg orally daily.[Ref]
1. Albin RL, Albers JW "Long-term follow-up of pyridoxine-induced acute sensory neuropathy- neuronopathy." Neurology 40 (1990): 1319
2. "Multum Information Services, Inc. Expert Review Panel"
3. Morimoto K, Kawada A, Hiruma M, Ishibashi A "Photosensitivity from pyridoxine hydrochloride (vitamin b-6)." J Am Acad Dermatol 35 (1996): 304-5
4. Camarasa JG, Serra-Baldrich E, Lluch M "Contact allergy to vitamin B6." Contact Dermatitis 23 (1990): 115
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