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Proferrin-ES Side Effects

Generic Name: heme iron polypeptide

Note: This page contains side effects data for the generic drug heme iron polypeptide. It is possible that some of the dosage forms included below may not apply to the brand name Proferrin-ES.

It is possible that some side effects of Proferrin-ES may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to heme iron polypeptide: oral tablet

Get emergency medical help if you have any of these signs of an allergic reaction while taking heme iron polypeptide (the active ingredient contained in Proferrin-ES) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Heme iron polypeptide may cause your urine or stools to turn a reddish-brown or dark color. This side effect is usually not harmful.

Common side effects may include:

  • upset stomach, gas;

  • diarrhea; or

  • constipation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to heme iron polypeptide: oral tablet

Other

Iron overload (i.e., hemosiderosis) has been reported in patients genetically predisposed, or have underlying disorders, that augment the absorption of iron. It has also occurred following administration of excessive parenteral iron therapy, combination of oral and parenteral iron, or in patients with hemoglobinopathies that were erroneously diagnosed as iron deficiency anemia. Hemosiderosis is treated with repeated phlebotomy or long-term administration of deferoxamine. The liver is particularly susceptible to toxicity in iron-overload states.

Other side effects associated with iron therapy have included iron overload (hemosiderosis).

Gastrointestinal

Gastrointestinal side effects have rarely included queasiness, dark green stool, and Hemoccult-positive stools.

Doses of heme iron polypeptide exceeding 56 mg of elemental iron have been reported to cause queasiness and dark green stool.

Patients who receive therapy with heme iron polypeptide and have a positive reaction to an occult stool test may require further work-up.

Immunologic

It has been hypothesized that gastroenteritis is caused by bacteria that become virulent in the presence of iron overload resulting in a systemic infection. Treatment consists of discontinuing deferoxamine and initiating appropriate antimicrobial therapy.

Immunologic side effects associated with iron therapy have rarely included gastroenteritis associated with Yersinia enterocolitica and Listeria monocytogenes in patients with iron overload status receiving treatment with deferoxamine.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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