Primacor Side Effects
Generic name: milrinone
Note: This document contains side effect information about milrinone. Some of the dosage forms listed on this page may not apply to the brand name Primacor.
Some side effects of Primacor may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to milrinone: intravenous solution
Get emergency medical help if you have any of these signs of an allergic reaction while taking milrinone (the active ingredient contained in Primacor) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers at once if you have a serious side effect such as:
feeling like you might pass out;
bronchospasm (wheezing, chest tightness, trouble breathing); or
low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling).
Less serious side effects of milrinone may include:
easy bruising or bleeding.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to milrinone: intravenous solution
Cardiovascular side effects have included ventricular arrhythmias (12%), ventricular ectopic activity (8%), supraventricular arrhythmias (3.8%), sustained and nonsustained ventricular tachycardia (1% and 2.8%, respectively), ventricular fibrillation (0.2%), and atrial fibrillation. Hypotension (2.9%) and angina/chest pain (1.2%) have occurred. In addition, rare reports of torsades de pointes have been reported in postmarketing experience.
Nervous system side effects have included headaches (2.9%) and tremor (0.4%). Dizziness is most often associated with hypotension.
Hematologic side effects of reversible thrombocytopenia (0.4%), inhibition of platelet activity, and increased bleeding time have occurred. While these effects have been described in patients undergoing cardiac surgery who had received milrinone (the active ingredient contained in Primacor) for 12 to 24 hours, they have not been associated with acute administration of milrinone. The hematologic side effects of milrinone may be important in some patients who are awaiting cardiac catheterization, transplant, or other significant invasive procedures.
Milrinone has been shown to inhibit human platelet thromboxane A2 synthesis and calcium uptake.
General gastrointestinal complaints have been reported rarely.
Hypersensitivity reactions including rare instances of bronchospasm and anaphylactic shock have been reported in postmarketing experience.
Hepatic side effects including liver function test abnormalities have been reported in postmarketing experience.
Other side effects including rash and skin reactions have been reported in postmarketing experience.
Metabolic side effects have included rare reports of hypokalemia (0.6%).
Respiratory side effects have been reported including isolated, spontaneous reports of bronchospasm.
Dermatologic side effects including rash has been reported in postmarketing experience.
Local side effects including infusion site reaction has been reported in postmarketing experience.
More Primacor resources
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