Primacor I.V. Side Effects

Generic Name: milrinone

Please note - some side effects for Primacor I.V. may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects by Body System

Cardiovascular

Cardiovascular side effects have included ventricular arrhythmias (12%), ventricular ectopic activity (8%), supraventricular arrhythmias (3.8%), sustained and nonsustained ventricular tachycardia (1% and 2.8%, respectively), and ventricular fibrillation (0.2%). Hypotension (2.9%) and angina/chest pain (1.2%) have occurred. In addition, rare reports of torsades de pointes have been reported in postmarketing experience.

Nervous system

Nervous system side effects have included headaches (2.9%) and tremor (0.4%). Dizziness is most often associated with hypotension.

Hematologic

Hematologic side effects of reversible thrombocytopenia (0.4%), inhibition of platelet activity, and increased bleeding time have occurred. While these effects have been described in patients undergoing cardiac surgery who had received milrinone for 12 to 24 hours, they have not been associated with acute administration of milrinone. The hematologic side effects of milrinone may be important in some patients who are awaiting cardiac catheterization, transplant, or other significant invasive procedures.

Milrinone has been shown to inhibit human platelet thromboxane A2 synthesis and calcium uptake.

Gastrointestinal

General gastrointestinal complaints have been reported rarely.

Hypersensitivity

Hypersensitivity reactions including rare instances of bronchospasm and anaphylactic shock have been reported in postmarketing experience.

Hepatic

Hepatic side effects including liver function test abnormalities have been reported in postmarketing experience.

Other

Other side effects including rash and skin reactions have been reported in postmarketing experience.

Metabolic

Metabolic side effects have included rare reports of hypokalemia (0.6%).

Respiratory

Respiratory side effects have been reported including isolated, spontaneous reports of bronchospasm.

Dermatologic

Dermatologic side effects including rash has been reported in postmarketing experience.

Local

Local side effects including infusion site reaction has been reported in postmarketing experience.

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