Premarin Cream Side Effects
Please note - some side effects for Premarin Cream may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
Side Effects by Body System - for Healthcare Professionals
Applies to: vaginal cream with applicator
Oncologic side effects have included an increased risks of endometrial carcinoma, ovarian cancer, and breast cancer.
Cardiovascular side effects have included deep and superficial venous thrombosis, pulmonary embolism, thrombophlebitis, increase in blood pressure, and myocardial infarction.
The manufacturer recommends close observation if conjugated estrogens must be used in patients who may be particularly sensitive to fluid retention because of underlying asthma, epilepsy, migraine, heart disease, and renal dysfunction.
Genitourinary side effects have included breakthrough bleeding, spotting, changes in vaginal bleeding pattern, abnormal withdrawal bleeding or flow, dysmenorrhea, increase the size of preexisting uterine leiomyomata, vaginitis, including vaginal candidiasis, change in cervical erosion and in degree of cervical secretion, cystitis like syndrome, application site reactions of vulvovaginal discomfort including burning and irritation, genital pruritus, ovarian cancer, endometrial hyperplasia, and precocious puberty. Additional side effects have included breast enlargement, breast pain, dysuria, leukorrhea, metrorrhagia, urinary frequency, urinary tract infection, urinary urgency, vaginal hemorrhage, vaginal moniliasis, vaginitis, and vulvovaginal disorder.
Metabolic side effects have included increased serum triglyceride levels and reduced carbohydrate tolerance. Aggravation of porphyria has been reported.
General side effects have included reports of fluid retention, and increase or decrease in weight.
Gastrointestinal side effects have included nausea, vomiting, abdominal cramps, bloating, cholestatic jaundice, pancreatitis, and increased incidence of gallbladder disease. Ischemic colitis has also been reported.
Hematologic side effects have included hypercoagulability. Several cases of the hemolytic uremic syndrome have also been associated with conjugated estrogen therapy.
Hepatic side effects have included enlargement of hepatic hemangiomas and rare cases of focal nodular hyperplasia, liver cell adenomas, hepatic hemangiomas and well differentiated hepatocellular carcinomas.
Many of the reports of hepatic tumors have occurred in women taking long-term oral contraceptives. However, some tumors have been reported in women taking isolated estrogen therapy.
Nervous system side effects have included migraine, dizziness, nervousness, mood disturbances, irritability, chorea, exacerbation of epilepsy, dementia, and mental depression. Possible growth potentiation of benign meningioma has also been reported.
Other side effects have included breast tenderness, pain, enlargement, secretion, and fibrocystic breast changes. Postmarketing experience has included reports of gynecomastia in males.
Psychiatric side effects have included reports of rapid mood cycling in patients with severe depression.
Hypersensitivity side effects have been reported in postmarketing experience.
Respiratory side effects have included pulmonary embolism, exacerbation of asthma, and rare cases of exacerbations of pulmonary lymphangioleiomyomatosis. In addition, combinations of high-dose conjugated estrogens and progestin have been reported to increase ventilation and increase the hypoxic ventilatory response.
Dermatologic side effects have included chloasma or melasma, which did not always resolve following discontinuation of estrogen therapy, scalp hair loss, hirsutism, erythema multiforme, erythema nodosum, rash, pruritus, and hemorrhagic eruptions. Acne and erythema have also been reported.
Endocrine side effects have included increased levels of thyroxin-binding globulin, leading to an increase in total thyroid serum levels and a decrease in resin uptake of T3. Free thyroid hormone levels remain unchanged. Other endocrine effects include decreased fasting plasma glucose.
Ocular side effects have included retinal vascular thrombosis and intolerance to contact lenses.
Musculoskeletal side effects have included muscle cramps.Top
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