Potassium phosphate Side Effects
Some side effects of potassium phosphate may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to potassium phosphate: intravenous solution
Along with its needed effects, potassium phosphate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking potassium phosphate:Incidence not known
- Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- chest pain or discomfort
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast, slow, or irregular heartbeat
- muscle cramps in the hands, arms, feet, legs, or face
- no muscle tone or movement
- numbness and tingling around the mouth, fingertips, or feet
- pounding or rapid pulse
- shortness of breath
- unusual tiredness or weakness
- weakness and heaviness of the legs
For Healthcare Professionals
Applies to potassium phosphate: intravenous solution, oral powder for reconstitution
Signs of hyperkalemia include muscle weakness, frank skeletal muscle and diaphragm paralysis, peaked T waves on the ECG, and cardiac arrhythmias. If toxicity is suspected or documented, potassium should be stopped immediately. While monitoring the ECG, a combination of dextrose and insulin in a ratio of 3 g of dextrose for every 1 unit of insulin may be administered. Sodium bicarbonate 50 to 100 mEq and calcium gluconate 10% intravenously may be helpful if acidosis is present. Potassium-binding resins or dialysis may be necessary in serious cases.
Hyperkalemia is significantly more likely in elderly patients with uremia who receive high doses.
In patients with renal failure, other factors that may cause hyperkalemia include defects in the renin-angiotensin-aldosterone axis, tubular defects in potassium secretion, intra- to extracellular potassium shifts due to metabolic acidosis, and possible high potassium loads from underlying disease states (such as rhabdomyolysis, hemolysis, gastrointestinal bleeding, etc.).
Renal failure is the most common cause of hyperphosphatemia. Other factors that may contribute to hyperphosphatemia in patients with renal insufficiency include high phosphorus intake, and rarely, hypoparathyroidism or acromegaly.
When severe, hyperphosphatemia may reduce the extracellular concentration of ionized calcium (increasing the risk of tetany) and increase the risk of extraosseous calcification.
Metabolic side effects have been reported the most frequently and have usually resulted from hyperkalemia and/or hyperphosphatemia. They have included muscle weakness, frank skeletal muscle and diaphragm paralysis, peaked T waves on the ECG, life-threatening cardiac arrhythmias and an increased risk of extraosseous calcification.
While the most common cause of hypokalemia in patients with liver cirrhosis is diuretic therapy, other causes include low dietary intake, enhanced renal loss due to hyperaldosteronism, magnesium deficiency, and accelerated gastrointestinal losses. Hypophosphatemia may be associated with malnutrition in some patients with alcoholic liver disease.
Gastrointestinal side effects have included diarrhea, nausea, stomach pains, and vomiting.
Cardiovascular side effects have included fast or irregular heartbeat, dyspnea, lower extremity edema, and unusual weight gain.
Nervous system side effects have included headaches, dizziness, thirst, mental confusion, seizures, weakness or heaviness of the legs, muscle cramps, numbness, tingling, and perioral tingling.
More potassium phosphate resources
- potassium phosphate Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information
- potassium phosphate MedFacts Consumer Leaflet (Wolters Kluwer)
- Neutra-Phos-K powder for solution MedFacts Consumer Leaflet (Wolters Kluwer)
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.