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Polysporin Ophthalmic Side Effects

Generic Name: bacitracin / polymyxin b ophthalmic

Note: This page contains side effects data for the generic drug bacitracin / polymyxin b ophthalmic. It is possible that some of the dosage forms included below may not apply to the brand name Polysporin Ophthalmic.

It is possible that some side effects of Polysporin Ophthalmic may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to bacitracin / polymyxin b ophthalmic: ophthalmic ointment

Get emergency medical help if you have any of these signs of an allergic reaction while taking bacitracin / polymyxin b ophthalmic: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have a serious side effect such as:

  • severe itching, redness, or swelling of your eyelids;

  • eye pain, redness, or watering;

  • vision changes, increased sensitivity to light;

  • white patches on your eyes;

  • crusting or drainage from your eyes; or

  • any new signs of infection.

Less serious side effects may include temporary blurred vision and mild eye irritation after using the ointment.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to bacitracin / polymyxin b ophthalmic: ophthalmic ointment


Hypersensitivity reactions have included itching, swelling and conjunctival erythema. More serious hypersensitivity reactions including anaphylaxis have been reported rarely.[Ref]


Local irritation upon application has been reported.[Ref]


1. "Product Information. Polysporin (bacitracin-polymyxin B ophthalmic)." Monarch Pharmaceuticals Inc, Bristol, TN.

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