Polymyxin B Side Effects

Please note - some side effects for Polymyxin B may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Polymyxin B - for the consumer

Polymyxin B Sulfate

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Polymyxin B Sulfate:

Fever; pain at the injection site.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); change in the amount of urine; change in hearing or ringing in the ears; dizziness; drowsiness; flushing of the face; loss of coordination; mental or mood change (eg, irritability); severe headache; stiff neck; swelling and redness at the injection site; tingling or numbness in the mouth, hands, or feet; unusual weakness; unusually fast heartbeat; vision changes.

Polymyxin B Sulfate/Trimethoprim Solution

All medicines may cause side effects, but many people have no, or minor, side effects. No COMMON side effects have been reported with Polymyxin B Sulfate/Trimethoprim Solution. Seek medical attention right away if any of these SEVERE side effects occur when using Polymyxin B Sulfate/Trimethoprim Solution:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); eyelid swelling; increased or persistent redness, irritation, swelling, pain, or tearing of the eye.

For the professional

Polymyxin B Injection

See WARNING box.

Nephrotoxic reactions:

Albuminuria, cylinduria, azotemia, and rising blood levels without any increase in dosage.

Neurotoxic reactions:

Facial flushing, dizziness progressing to ataxia, drowsiness, peripheral paresthesias (circumoral and stocking glove), apnea due to concurrent use of curariform muscle relaxants, other neurotoxic drugs or inadvertent overdosage, and signs of meningeal irritation with intrathecal administration, e.g., fever, headache, stiff neck and increased cell count and protein cerebrospinal fluid.

Other reactions occasionally reported:

Drug fever, urticarial rash, pain (severe) at intramuscular injection sites, and thrombophlebitis at intravenous injection sites.

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