Plegine Side Effects

Generic Name: phendimetrazine

Note: This page contains side effects data for the generic drug phendimetrazine. It is possible that some of the dosage forms included below may not apply to the brand name Plegine.

It is possible that some side effects of Plegine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to phendimetrazine: oral capsule, oral capsule extended release, oral tablet

As well as its needed effects, phendimetrazine (the active ingredient contained in Plegine) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking phendimetrazine, check with your doctor immediately:

Rare
  • Seeing, hearing, or feeling things that are not there
  • severe mental changes
Incidence not known
  • Anxiety
  • burning while urinating
  • chest pain or discomfort
  • decreased ability to exercise
  • difficult or painful urination
  • dizziness
  • dry mouth
  • fainting
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling of warmth
  • headache
  • hyperventilation
  • increased need to urinate
  • irritability
  • nausea
  • numbness or tingling in the arms or legs
  • pain or discomfort in the arms, jaw, back, or neck
  • passing urine more often
  • redness of the face, neck, arms, and occasionally, upper chest
  • restlessness
  • shakiness in the legs, arms, hands, or feet
  • shortness of breath
  • sweating
  • swelling of the feet or lower legs
  • trembling or shaking of the hands or feet
  • trouble with breathing
  • trouble with sleeping
  • trouble with thinking, speaking, or walking
  • vomiting
  • weakness

If any of the following symptoms of overdose occur while taking phendimetrazine, get emergency help immediately:

Symptoms of overdose
  • Abdominal or stomach cramps
  • blurred vision
  • change in consciousness
  • convulsions
  • diarrhea
  • discouragement
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast, slow, or irregular heartbeat
  • feeling sad or empty
  • lack of appetite
  • lightheadedness
  • loss of consciousness
  • loss of interest or pleasure
  • overactive reflexes
  • panic
  • physical attempt to injure
  • pounding in the ears
  • rapid breathing
  • sweating
  • tiredness
  • trouble with concentrating
  • unusual tiredness or weakness
  • violent actions

Some phendimetrazine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known
  • Decreased interest in sexual intercourse
  • difficulty having a bowel movement (stool)
  • inability to have or keep an erection
  • increased in sexual ability, desire, drive, or performance
  • increased interest in sexual intercourse
  • loss in sexual ability, desire, drive, or performance
  • sleeplessness
  • stomach pain
  • unable to sleep

For Healthcare Professionals

Applies to phendimetrazine: oral capsule extended release, oral tablet

Cardiovascular

Cardiovascular side effects including palpitation, tachycardia, and elevation of blood pressure have been reported. A case of dilated cardiomyopathy has been associated with chronic use of phendimetrazine (the active ingredient contained in Plegine) [Ref]

Nervous system

Nervous system side effects including overstimulation, restlessness, dizziness, insomnia, tremor, and headache have been reported. Psychotic episodes (at recommended doses), agitation, flushing, and sweating have been reported rarely.[Ref]

Gastrointestinal

Gastrointestinal side effects including dryness of mouth, diarrhea, constipation, nausea, and stomach pain have been reported.[Ref]

Genitourinary

Genitourinary side effects including changes in libido, urinary frequency, and dysuria have been reported.[Ref]

Ocular

Ocular side effects including blurring of vision have been reported.[Ref]

References

1. "Product Information. Prelu-2 (phendimetrazine)" Boehringer-Ingelheim, Ridgefield, CT.

2. Rostagno C, Caciolli S, Felici M, Gori F, Neri Serneri GG "Dilated cardiomyopathy associated with chronic consumption of phendimetrazine." Am Heart J 131 (1996): 407-9

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide
(web1)