Piloptic-1 Side Effects
Generic Name: pilocarpine ophthalmic
Note: This page contains side effects data for the generic drug pilocarpine ophthalmic. It is possible that some of the dosage forms included below may not apply to the brand name Piloptic-1.
It is possible that some side effects of Piloptic-1 may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to pilocarpine ophthalmic: ophthalmic device, ophthalmic gel/jelly, ophthalmic solution, ophthalmic suspension
As well as its needed effects, pilocarpine ophthalmic (the active ingredient contained in Piloptic-1) may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking pilocarpine ophthalmic, check with your doctor or nurse as soon as possible:Symptoms of too much medicine being absorbed into the body
- Increased sweating
- muscle tremors
- nausea, vomiting, or diarrhea
- troubled breathing or wheezing
- watering of mouth
- Eye pain
Some pilocarpine ophthalmic side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common
- Blurred vision or change in near or far vision
- decrease in night vision
- Eye irritation
- headache or browache
For Healthcare Professionals
Applies to pilocarpine ophthalmic: compounding powder, ophthalmic gel, ophthalmic insert, ophthalmic solution
The results of small studies have suggested that patients with depression or Alzheimer's disease may have greater sensitivity to the muscarinic effects of pilocarpine.[Ref]
Ocular side effects with the ophthalmic gel or solution have included lacrimation, burning, local discomfort, temporal or supraorbital headache, ciliary spasm, conjunctival vascular congestion, superficial keratitis, and induced myopia. Reduced visual acuity in poor illumination is frequently experienced in older individuals and in those with lens opacity. A subtle corneal granularity was observed in approximately 10% of patients. Cases of retinal detachment have been associated with the use of miotic agents, especially in young myopic patients. Lens opacity may occur after prolonged use of this drug. Ocular reactions usually occur during initiation of therapy and often will not persist with continued use.
Ocular side effects with pilocarpine ocular inserts have included ciliary spasm (often resulting in transient myopia), local irritation, corneal abrasions, and visual impairment. In some cases, local irritation, allergic reactions, or induced myopia necessitates cessation of therapy. Cases of retinal detachment have been associated with the use of miotic agents, especially in young myopic patients. Some patients may experience conjunctival irritation, including mild erythema with or without increased mucous secretion near the initiation of therapy that tends to subside with continued use. Although rare, increased pilocarpine effect has been observed during therapy.[Ref]
General side effects have included sweating and gastrointestinal overactivity in rare circumstances.[Ref]
1. "Product Information. Pilopine HS (pilocarpine ophthalmic)." Alcon Laboratories Inc, Fort Worth, TX.
2. Sokolski KN, Demet EM "Increased pupillary sensitivity to pilocarpine in depression." Prog Neuropsychopharmacol Biol Psychiatry 20 (1996): 253-62
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