Pilocarpine Side Effects

It is possible that some side effects of pilocarpine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to pilocarpine: oral tablet

As well as its needed effects, pilocarpine may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking pilocarpine, check with your doctor or nurse as soon as possible:

Symptoms of overdose
  • Chest pain
  • confusion
  • diarrhea (continuing or severe)
  • fainting
  • fast, slow, or irregular heartbeat (continuing or severe)
  • headache (continuing or severe)
  • nausea or vomiting (continuing or severe)
  • shortness of breath or troubled breathing
  • stomach cramps or pain
  • tiredness or weakness (continuing or severe)
  • trembling or shaking (continuing or severe)
  • trouble seeing (continuing or severe)

Some pilocarpine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common
  • Chills
  • cough
  • diarrhea
  • feeling of warmth or heat
  • fever
  • flushing or redness of skin especially on face and neck
  • increased need to urinate
  • indigestion
  • joint pain
  • muscle aches and pains
  • nausea
  • passing urine more often
  • runny nose
  • unusual tiredness or weakness
  • Sweating
Less common or rare
  • fast heartbeat
  • headache
  • holding more body water
  • swelling of face, fingers, ankles, or feet
  • trembling or shaking
  • trouble swallowing
  • trouble seeing
  • unusual weak feeling
  • voice change
  • vomiting

For Healthcare Professionals

Applies to pilocarpine: compounding crystal, compounding powder, oral tablet

Gastrointestinal

Gastrointestinal side effects commonly reported have included nausea (6% to 15%), diarrhea (4% to 7%), dyspepsia (7%), abdominal pain (4%), and vomiting (4%). Anorexia, increased appetite, cholelithiasis, flatulence, gastritis, gastroenteritis, gastrointestinal disorder, and tongue disorder have been reported rarely.

Respiratory

Respiratory side effects have included rhinitis (5% to 14%), sinusitis (4%), and pharyngitis (2%). Esophagitis, increased sputum, stridor, yawning, bronchitis, dyspnea, hiccup, laryngismus, laryngitis, and voice alteration have been reported infrequently.

Endocrine

Endocrine side effects have included sweating (29% to 68%), lacrimation (6%), and increased salivation (3%).

Cardiovascular

Cardiovascular side effects have included hypertension (3%), angina pectoris, arrhythmia, electrocardiogram abnormality, hypotension, myocardial infarction, tachycardia, bradycardia, palpitations, and syncope.

Nervous system

Nervous system side effects commonly reported have included asthenia (6% to 12%) and dizziness (5% to 12%). Aphasia, confusion, abnormal dreams, hyperkinesia, hypesthesia, insomnia, myalgia, paresthesias, abnormal thinking, speech disorder, twitching, and tremor have been reported less frequently.

Ocular

Ocular side effects have included amblyopia, cataract, conjunctivitis, dry eyes, blurred vision, eye disorder, eye pain, eye hemorrhage, glaucoma, retinal disorder, and abnormal vision.

Genitourinary

Genitourinary side effects have included dysuria, metrorrhagia, urinary impairment, urinary incontinence, urinary tract infection, vaginitis, breast pain, mastitis, menorrhagia, ovarian disorder, pyuria, salpingitis, urethral pain, urinary urgency, vaginal hemorrhage, and vaginal moniliasis.

Psychiatric

Psychiatric side effects have included anxiety, confusion, depression, abnormal dreams, somnolence, emotional lability, insomnia, and nervousness.

Hematologic

Hematologic side effects have included leukopenia, lymphadenopathy, hematuria, abnormal platelets, thrombocythemia, thrombocytopenia, thrombosis, and abnormal WBC.

Metabolic

Metabolic side effects have included hypoglycemia.

Dermatologic

Dermatologic side effects have included seborrhea.

Other

Other infrequently reported side effects have included cyst, neck pain, neck rigidity, photosensitivity reaction, body odor, taste loss, taste perversion, voice alteration, tongue disorder, tooth disorder, increased cough, fever, and lab test abnormalities.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide
(web2)