Phentermine and topiramate Side Effects
Please note - some side effects for Phentermine and topiramate may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
Side Effects by Body System - for Healthcare Professionals
Cardiovascular side effects have included palpitations (up to 2.4%) and chest discomfort (up to 2.1%).
Dermatologic side effects have included rash (up to 2.6%) and alopecia (up to 3.7%).
Gastrointestinal side effects have included constipation (up to 16.1%), dry mouth (up to 19.1%), nausea (up to 7.2%), dyspepsia (up to 2.8%), gastroesophageal reflux disease (up to 2.6%), gastroenteritis (up to 2.5%), decreased appetite (up to 2.1%), paresthesia oral (up to 2.2%), and thirst (up to 2%).
Genitourinary side effects have included urinary tract infection (up to 5.2%) and dysmenorrhea (up to 2.1%).
Hepatic side effects have included nephrolithiasis (up to 1.2%).
Immunologic side effects have included influenza (up to 6.7%).
Metabolic side effects have included hypokalemia (up to 2.5%), decreased serum bicarbonate (up to 8.8%), decreased serum potassium (up to 4.9%) and decreased serum creatinine (up to 2.5%).
Musculoskeletal side effects have included and back pain (up to 6.6%), pain in extremity (up to 3%), muscle spasms (up to 2.9%), musculoskeletal pain (up to 3%), and neck pain (up to 2.2%).
Nervous system side effects have included paresthesia (up to 19.9%), headache (up to 10.6%), dizziness (up to 8.6%), dysgeusia (up to 9.4%), fatigue (up to 5.9%), irritability (up to 3.7%), hypoesthesia (up to 3.7%), and disturbance in attention (up to 3.5%).
Ocular side effects have included blurred vision (up to 6.3%), eye pain (up to 2.2%), and dry eye (up to 2.5%).
Other side effects of phentermine reported postmarketing have included allergic reactions, urticaria, cardiovascular adverse reactions, elevation of blood pressure, ischemic events, central nervous system adverse reactions, euphoria, psychosis, tremor, reproductive adverse reactions, changes in libido, and impotence. Other side effects of topiramate reported postmarketing have included dermatologic disorders, bullous skin reactions (including erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis), pemphigus, gastrointestinal disorders, pancreatitis, hepatic disorders, hepatic failure (including fatalities), hepatitis, metabolic disorders, hyperammonemia, hypothermia, ophthalmic disorders, and maculopathy.
Psychiatric side effects have included insomnia (up to 9.4%), depression (up to 4.3%), and anxiety (up to 4.1%).
Respiratory side effects have included upper respiratory tract infection (up to 15.8%), nasopharyngitis (up to 12.5%), sinusitis (up to 7.8%), bronchitis (up to 6.7%), cough (up to 4.8%), sinus congestion (up to 2.6%), pharyngolaryngeal pain (up to 2.5%), and nasal congestion (up to 2%).Top
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