Perdiem Side Effects

Please note - some side effects for Perdiem may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects by Body System

Gastrointestinal

Gastrointestinal side effects have included several cases of esophageal impaction and duodenal bezoars in patients receiving a bulk laxative product containing 82% psyllium and 18% senna (commercially available as Perdiem Overnight Relief).

Hypersensitivity

While hypersensitivity reactions to psyllium may be severe, they are most frequently reported by workers in the pharmaceutical firms that manufacture the drug. This is because when it is mixed or poured, fine dust particles are readily dispersed into the air and can then be inhaled and cause sensitization. Orally ingested psyllium seems less likely to induce sensitization.

A case has been reported of a factory worker who developed IgE-mediated asthma and rhinoconjunctivitis five months after exposure to senna.

Hypersensitivity side effects have been reported rarely. They have included sensitization to psyllium resulting from inhalation of fine dust particles dispersed into the air as the product is mixed or poured. Occupational sensitization to senna has been reported rarely.

Hematologic

The case report of eosinophilia was believed to be a sole manifestation of an allergic reaction to psyllium.

Hematologic side effects have included a case of eosinophilia in a patient receiving psyllium.

Musculoskeletal

Musculoskeletal side effects include a case of finger clubbing presumed to be associated with senna use.

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