Penicillin v potassium Side Effects
Please note - some side effects for Penicillin v potassium may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
Side Effects of Penicillin v potassium - for the Consumer
Penicillin v potassium
Applies to: tablets
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Penicillin v potassium:
Seek medical attention right away if any of these SEVERE side effects occur when using Penicillin v potassium:
Black, hairy tongue; irritation of the mouth or throat; mild diarrhea; nausea; upset stomach; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools or urine; fever, chills, or persistent sore throat; severe or persistent diarrhea; stomach pain or cramps; unusual bruising or bleeding; vaginal irritation or itching; worsening of skin lesions.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.Top
Side Effects by Body System - for Healthcare Professionals
Applies to: oral powder for reconstitution; oral tablet
In general, side effects associated with oral penicillin therapy have been reported much less frequently than with parenteral penicillin therapy. However, all degrees of hypersensitivity, including fatal anaphylaxis, have been reported with oral penicillin.
Gastrointestinal side effects have included nausea, vomiting, epigastric distress, diarrhea, and black hairy tongue. Clostridium difficile associated diarrhea has been reported and may occur during or after therapy. Pancreatitis, intestinal necrosis, and blood in the stool have also been reported.
Hypersensitivity side effects have included skin eruptions (maculopapular to exfoliative dermatitis), pruritus, urticaria, laryngeal edema, fever, eosinophilia, hypersensitivity myocarditis, serum sickness-like reactions (chills, fever, edema, arthralgia, and prostration), severe or fatal anaphylaxis, shock, and death.
Hypersensitivity reactions with penicillin are more common and more serious with intravenous therapy, but have also been reported with oral therapy. An initial sensitizing exposure is required to stimulate the production of antigen-specific IgE before clinical manifestations of hypersensitivity are seen on the second exposure. There are numerous "hidden" environmental or occupational exposures to penicillin including in utero exposure, breast milk exposure, and occupational exposure.
Dermatologic side effects have included rash, peeling, mucosal ulceration, and urticaria.
Hematologic side effects have included hemolytic anemia, anemia, leukopenia, thrombocytopenia, and lymphadenopathy.
Hepatic side effects have included increased SGOT, reversible hepatotoxicity, jaundice, and prolonged cholestasis.
Nervous system side effects have included severe reactions with high dose penicillin therapy or in patients with renal dysfunction. These reactions have included myoclonus, seizures, auditory and visual hallucinations, and decreased mentation. Neurologic reactions occurred frequently in patients with renal dysfunction. Aseptic meningitis has been reported.
Severe neurologic reactions were most often seen with penicillin doses of 18 million to 80 million units daily. These reactions frequently abated after discontinuation of penicillin. In several cases, penicillin was restarted at a lower dose with no further sequelae. In one review, the authors found that cerebral spinal fluid (CSF) penicillin levels were higher in patients with seizures than in those without. CSF penicillin levels ranged from 12 to 61 units/mL in the seizure group with the highest CSF concentrations, compared to 7.8 units/mL in the group without seizures.
Other side effects have included fatigue, asthenia, pain, abnormal taste perception, tinnitus, and aggravation of existing disorders.
Respiratory side effects have included hypoxia, apnea, and dyspnea.Top
- penicillin v potassium MedFacts Consumer Leaflet (Wolters Kluwer)
- Penicillin V Potassium Prescribing Information (FDA)
- Penicillin V Potassium Monograph (AHFS DI)
- penicillin V potassium Concise Consumer Information (Cerner Multum)
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