Penetrex Side Effects

Please note - some side effects for Penetrex may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Side Effects by Body System - for Healthcare Professionals

General

Enoxacin therapy is generally well tolerated, and adverse effects are mild in nature. Discontinuation of therapy due to adverse effects occurs in approximately 3% of patients.

Gastrointestinal

Gastrointestinal disturbances due to enoxacin therapy may occur in up to 9% of patients. This most frequently includes nausea, abdominal pain, anorexia, dyspepsia, and diarrhea. Enoxacin therapy has resulted in pseudomembranous colitis although it has minimal effect on the anaerobic flora of the GI tract.

Nervous system

Nervous system adverse effects occur in approximately 2% to 3% of patients. These most commonly include headache, dizziness, fatigue, nervousness, agitation, and insomnia. Seizures have also been reported in susceptible patients.

Hypersensitivity

Hypersensitivity reactions resulting in rash and pruritus have been reported in up to 1% of patients treated with enoxacin. Photosensitivity can occur. Erythema multiforme, toxic epidermal necrolysis, and Stevens-Johnson Syndrome have also been reported.

Hepatic

Asymptomatic elevations in hepatic transaminases have been reported in less than 1% of patients treated with enoxacin. Cholestatic jaundice has been reported in one patient shortly after enoxacin administration.

Hematologic

Hematologic abnormalities such as eosinophilia and leukopenia occur in less than 1% of enoxacin-treated patients.

Musculoskeletal

Arthralgias and myalgias occur rarely.

Cardiovascular

Tachycardia and facial flushing have been reported rarely.

Other

Women treated with enoxacin may experience vaginal pruritus and vaginitis.

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