Penetrex Side Effects
Generic name: enoxacin
Note: This document contains side effect information about enoxacin. Some of the dosage forms listed on this page may not apply to the brand name Penetrex.
Some side effects of Penetrex may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to enoxacin: oral tablet
If you experience any of the following serious side effects, stop taking enoxacin (the active ingredient contained in Penetrex) and seek emergency medical attention or contact your doctor immediately:
an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
confusion or hallucinations;
liver damage (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, severe fatigue); or
muscle or joint pain.
If you experience any of the following less serious side effects, continue taking enoxacin and talk to your doctor:
nausea, vomiting, or diarrhea;
headache, lightheadedness, or drowsiness;
ringing in your ears; or
increased sensitivity of the skin to sunlight.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
For Healthcare Professionals
Applies to enoxacin: oral tablet
Enoxacin (the active ingredient contained in Penetrex) therapy is generally well tolerated, and adverse effects are mild in nature. Discontinuation of therapy due to adverse effects occurs in approximately 3% of patients.
Gastrointestinal disturbances due to enoxacin (the active ingredient contained in Penetrex) therapy may occur in up to 9% of patients. This most frequently includes nausea, abdominal pain, anorexia, dyspepsia, and diarrhea. Enoxacin therapy has resulted in pseudomembranous colitis although it has minimal effect on the anaerobic flora of the GI tract.
Nervous system adverse effects occur in approximately 2% to 3% of patients. These most commonly include headache, dizziness, fatigue, nervousness, agitation, and insomnia. Seizures have also been reported in susceptible patients.
Hypersensitivity reactions resulting in rash and pruritus have been reported in up to 1% of patients treated with enoxacin (the active ingredient contained in Penetrex) Photosensitivity can occur. Erythema multiforme, toxic epidermal necrolysis, and Stevens-Johnson Syndrome have also been reported.
Asymptomatic elevations in hepatic transaminases have been reported in less than 1% of patients treated with enoxacin (the active ingredient contained in Penetrex) Cholestatic jaundice has been reported in one patient shortly after enoxacin administration.
Hematologic abnormalities such as eosinophilia and leukopenia occur in less than 1% of enoxacin-treated patients.
Arthralgias and myalgias occur rarely.
Tachycardia and facial flushing have been reported rarely.
Women treated with enoxacin (the active ingredient contained in Penetrex) may experience vaginal pruritus and vaginitis.
More Penetrex resources
- Penetrex Concise Consumer Information (Cerner Multum)
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