Penetrex Side Effects
Generic Name: enoxacin
Note: This page contains side effects data for the generic drug enoxacin. It is possible that some of the dosage forms included below may not apply to the brand name Penetrex.
For the Consumer
Applies to enoxacin: oral tablet
If you experience any of the following serious side effects, stop taking enoxacin (the active ingredient contained in Penetrex) and seek emergency medical attention or contact your doctor immediately:
an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
confusion or hallucinations;
liver damage (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, severe fatigue); or
muscle or joint pain.
If you experience any of the following less serious side effects, continue taking enoxacin and talk to your doctor:
nausea, vomiting, or diarrhea;
headache, lightheadedness, or drowsiness;
ringing in your ears; or
increased sensitivity of the skin to sunlight.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
For Healthcare Professionals
Applies to enoxacin: oral tablet
Enoxacin (the active ingredient contained in Penetrex) therapy is generally well tolerated, and adverse effects are mild in nature. Discontinuation of therapy due to adverse effects occurs in approximately 3% of patients.[Ref]
Gastrointestinal disturbances due to enoxacin (the active ingredient contained in Penetrex) therapy may occur in up to 9% of patients. This most frequently includes nausea, abdominal pain, anorexia, dyspepsia, and diarrhea. Enoxacin therapy has resulted in pseudomembranous colitis although it has minimal effect on the anaerobic flora of the GI tract.[Ref]
Nervous system adverse effects occur in approximately 2% to 3% of patients. These most commonly include headache, dizziness, fatigue, nervousness, agitation, and insomnia. Seizures have also been reported in susceptible patients.[Ref]
Hypersensitivity reactions resulting in rash and pruritus have been reported in up to 1% of patients treated with enoxacin (the active ingredient contained in Penetrex) Photosensitivity can occur. Erythema multiforme, toxic epidermal necrolysis, and Stevens-Johnson Syndrome have also been reported.[Ref]
Asymptomatic elevations in hepatic transaminases have been reported in less than 1% of patients treated with enoxacin (the active ingredient contained in Penetrex) Cholestatic jaundice has been reported in one patient shortly after enoxacin administration.[Ref]
Hematologic abnormalities such as eosinophilia and leukopenia occur in less than 1% of enoxacin-treated patients.[Ref]
Arthralgias and myalgias occur rarely.[Ref]
Tachycardia and facial flushing have been reported rarely.[Ref]
Women treated with enoxacin (the active ingredient contained in Penetrex) may experience vaginal pruritus and vaginitis.[Ref]
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2. Foot M, Williams G, Want S, et al "An open study of the safety and efficacy of enoxacin in complicated urinary tract infections." J Antimicrob Chemother 21 (1988): 97-103
3. Bailey RR, Gorrie SI, Peddie BA, Davies PR "Double blind, randomised trial comparing single dose enoxacin and trimethoprim for treatment of bacterial cystitis." N Z Med J 100 (1987): 618-9
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5. Bailey RR, Walker RJ, Lynn KL, et al "Intravenous enoxacin for the treatment of pylenephritis: pharmacokinetic and clinical study." Br J Clin Pharmacol 25 (1988): 223-8
6. Naber KG, Sorgel F, Gutzler F, Bartosik-Wich B "In vitro activity, pharmacokinetics, clinical safety and therapeutic efficacy of enoxacin in the treatment of patients with complicated urinary tract infections." Infection 23 (1985): 219-24
7. Edlund C, Lidbeck A, Kager L, Nord CE "Effect of enoxacin on colonic microflora of healthy volunteers." Eur J Clin Microbiol 6 (1987): 298-300
8. "Product Information. Penetrex (enoxacin)." Rhone-Poulenc Rorer, Collegeville, PA.
9. Just PM "Overview of the fluoroquinolone antibiotics." Pharmacotherapy 13 (1993): s4-17
10. Tsuei SE, Darragh AS, Brick I "Pharmacokinetics and tolerance of enoxacin in healthy volunteers administered at a dosage of 400 mg twice daily for 14 days." J Antimicrob Chemother 14 (1984): 71-4
11. Edlund C, Lidbeck A, Kager L, Nord CE "Comparative effects of enoxacin and norfloxacin on human colonic microflora." Antimicrob Agents Chemother 31 (1987): 1846-8
12. Kang JS, Kim TH, Park KB, Chung BH, Youn JI "Enoxacin photosensitivity." Photodermatol Photoimmunol Photomed 9 (1993): 159-61
13. Kawabe Y, Mizuno N, Sakakibara S "Photoallergic reaction caused by enoxacin." Photodermatol 6 (1989): 58-60
14. Petri H, Tronnier H "Efficacy of enoxacin in the treatment of bacterial infections of the skin with regards to photosensitization." Infection 14 (1986): s213-16
15. Amitrano L, Gigliotti T, Guardascione MA, Ascione A "Acute cholestatic liver injury induced by enoxacin." J Hepatol 18 (1993): 139-40
It is possible that some side effects of Penetrex may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
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