Paser Side Effects
Generic Name: aminosalicylic acid
Note: This page contains side effects data for the generic drug aminosalicylic acid. It is possible that some of the dosage forms included below may not apply to the brand name Paser.
More frequent side effects include: eosinophilia and leukocytosis. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to aminosalicylic acid: oral tablet
As well as its needed effects, aminosalicylic acid (the active ingredient contained in Paser) may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking aminosalicylic acid, check with your doctor immediately:More common
- joint pains
- skin rash or itching
- unusual tiredness or weakness
- Abdominal pain (severe)
- lower back pain
- pain or burning while urinating
- paleness of skin
- sore throat
- yellow eyes or skin
If any of the following side effects occur while taking aminosalicylic acid, check with your doctor or nurse as soon as possible:Less common - with long-term, high-dose therapy
- Changes in menstrual periods
- decreased sexual ability in males
- dry, puffy skin
- swelling of front part of neck
- weight gain (unusual)
Some aminosalicylic acid side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common
- loss of appetite
- nausea and vomiting
- stomach pain (mild)
For Healthcare Professionals
Applies to aminosalicylic acid: compounding powder, oral granule enteric coated
Gastrointestinal side effects have been reported the most frequently. These have included nausea, vomiting, and abdominal pain.[Ref]
The incidence of gastrointestinal side effects is reduced with lower doses (8 g daily) and with the granular formulation of the drug.[Ref]
Hypersensitivity side effects have been reported rarely. The first signs have included rash, often followed by fever, and much less frequently, anorexia, nausea or diarrhea. The drug has been restarted in small but gradually increasing doses under a closely followed desensitization protocol.[Ref]
Patients should be closely monitored during the first three months of therapy and treatment must be discontinued immediately at the first signs of rash, fever, jaundice, or other sign of intolerance.[Ref]
Hepatic side effects have included jaundice and hepatitis. In patients diagnosed with hepatitis, hepatomegaly was invariably present with lymphadenopathy (45%), leukocytosis (79%), and eosinophilia (55%). Prompt recognition of symptoms with discontinuation of therapy led to recovery. Failure to recognize symptoms of liver injury can result in a mortality of up to 21%.[Ref]
A reduction in thyroxine synthesis has been associated with the administration of the sodium salt of aminosalicylic acid (the active ingredient contained in Paser) The development of goiter can be prevented by the administration of thyroxine but not iodide.[Ref]
Endocrine side effects have included hypothyroidism, especially with prolonged administration. It may be accompanied by goiter development.[Ref]
Hematologic side effects have included leukopenia, agranulocytosis, thrombocytopenia, Coombs' positive hemolytic anemia, and reduction in prothrombin.[Ref]
1. "Product Information. Paser Granules (aminosalicylic acid)." Jacobus Pharmaceutical Company, Princeton, NJ.
2. American Thoracic Society, CDC, Infectious Diseases Society of America "Treatment of tuberculosis." MMWR Morb Mortal Wkly Rep 53 (2005): 1203
It is possible that some side effects of Paser may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
More about Paser (aminosalicylic acid)
Related treatment guides
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.