Parathyroid hormone Side Effects
Medically reviewed by Drugs.com. Last updated on Nov 1, 2023.
Applies to parathyroid hormone: parenteral powder for injection.
Warning
REMS:
FDA approved a REMS for parathyroid hormone to ensure that the benefits outweigh the risks. The REMS may apply to one or more preparations of parathyroid hormone and consists of the following: elements to assure safe use and implementation system. See the FDA REMS page ([Web]).
Side effects include:
Paresthesia, hypocalcemia, headache, hypercalcemia, nausea, hypoesthesia, diarrhea, vomiting, arthralgia, hypercalciuria, extremity pain, upper respiratory tract infection, upper abdominal pain, sinusitis, decreased 25-hydroxycholecalciferol concentration, hypertension, facial hypoesthesia, neck pain.
For Healthcare Professionals
Applies to parathyroid hormone: subcutaneous powder for injection.
General
The more commonly reported adverse reactions have included paresthesia, hypocalcemia, headache, hypercalcemia, nausea, hypoesthesia, diarrhea, vomiting, arthralgia, hypercalciuria, and extremity pain.
Metabolic
Hypocalcemia combines reported events of hypocalcemia and blood calcium decreased; hypercalciuria combines reported events of hypercalciuria and urine calcium increased; and hypercalcemia combines reported events of hypercalcemia and blood calcium increased.
During clinical trials, 3 patients receiving this drug required IV fluids to correct hypercalcemia. In the postmarketing period, seizures due to hypocalcemia have been reported. The risk of hypocalcemia increases when this drug is withdrawn.[Ref]
Very common (10% or more): Hypocalcemia (27%), hypercalcemia (19%); hypercalciuria (11%)[Ref]
Nervous system
Very common (10% or more): Paresthesia (31%), headache (25%), hypoesthesia (14%)
Common (1% to 10%): Facial hypoesthesia
Postmarketing reports: Seizures due to hypocalcemia[Ref]
Hypersensitivity
Postmarketing reports: Hypersensitivity reactions including anaphylaxis, dyspnea, angioedema, urticaria, rash
Cardiovascular
Common (1% to 10%): Hypertension[Ref]
Gastrointestinal
Very common (10% or more): Nausea (18%), diarrhea (12%), vomiting (12%)
Common (1% to 10%): Upper abdominal pain[Ref]
Musculoskeletal
Very common (10% or more): Arthralgia (11%), pain in extremity (10%)
Common (1% to 10%): Neck pain[Ref]
Immunologic
Common (1% to 10%): Immunogenicity[Ref]
Genitourinary
Common (1% to 10%): Blood 25-hydroxycholecalciferol decreased[Ref]
Respiratory
Common (1% to 10%): Upper respiratory tract infection, sinusitis[Ref]
More about parathyroid hormone
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- Reviews (6)
- Latest FDA alerts (1)
- Dosage information
- During pregnancy
- Drug class: parathyroid hormone and analogs
- Breastfeeding
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References
1. Product Information. Natpara (parathyroid hormone). NPS Pharmaceuticals. 2015.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.