Oxytocin Side Effects

It is possible that some side effects of oxytocin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to oxytocin: solution

As well as its needed effects, oxytocin may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking oxytocin, check with your doctor or nurse immediately:

Rare
  • Confusion
  • convulsions (seizures)
  • difficulty in breathing
  • dizziness
  • fast or irregular heartbeat
  • headache (continuing or severe)
  • hives
  • pelvic or abdominal pain (severe)
  • skin rash or itching
  • vaginal bleeding (increased or continuing)
  • weakness
  • weight gain (rapid)
Incidence not known
  • Abdominal pain or cramping
  • blood clotting problem that causes prolonged bleeding
  • chest pain or discomfort
  • cough
  • difficulty swallowing
  • extra heartbeats
  • fainting
  • lightheadedness
  • pounding or rapid pulse
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • severe bleeding after giving birth
  • shortness of breath
  • tightness in the chest
  • unusual tiredness or weakness
  • wheezing

If any of the following symptoms of overdose occur while taking oxytocin, get emergency help immediately:

Symptoms of overdose
  • Restlessness
  • shakiness
  • sleepiness
  • slow to respond
  • slurred speech
  • unconsciousness

Some oxytocin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Rare
  • Nausea
  • vomiting

For Healthcare Professionals

Applies to oxytocin: compounding powder, injectable solution

Cardiovascular

Cardiovascular side effects have included hypertension, premature ventricular contractions, sinus tachycardia, and other cardiac arrhythmias. Neonatal bradycardia, premature ventricular contractions and other arrhythmias have been reported.

Nervous system

Nervous system side effects have included mania-like disturbances and seizures. The seizures may have been related to water intoxication. Neonatal seizures and permanent CNS or brain damage has been reported.

Metabolic

Metabolic side effects have included water intoxication resulting in coma and seizures.

Hypersensitivity

Hypersensitivity side effects have included anaphylactic reactions.

Genitourinary

Genitourinary side effects have included pelvic hematoma. Excessive doses have produced pelvic fracture, uterine hypertonicity, spasm, tetanic contraction and rupture.

Hematologic

Hematologic side effects have included postpartum hemorrhage and fatal afibrinogenemia.

Hepatic

Hepatic side effects have included neonatal jaundice.

Gastrointestinal

Gastrointestinal side effects have included nausea and vomiting.

Respiratory

Respiratory side effects have included pulmonary edema.

Renal

Renal side effects have included decreases in glomerular filtration rate and renal plasma flow. Doses of 40 milliunits per minute may produce significant decreases in urine output.

Local

Local side effects have included nasal irritation and rhinorrhea.

Ocular

Ocular side effects have included neonatal retinal hemorrhages.

Psychiatric

Psychiatric side effects have included memory impairment and mania in patients on high doses.

General

General side effects have include low Apgar scores at 5 minutes. Fetal death has been reported.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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