Oxyfast Side Effects

Generic name: oxycodone

Note: This document contains side effect information about oxycodone. Some of the dosage forms listed on this page may not apply to the brand name Oxyfast.

Some side effects of Oxyfast may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to oxycodone: oral capsule, oral concentrate, oral solution, oral tablet, oral tablet extended release

Get emergency medical help if you have any of these signs of an allergic reaction while taking oxycodone (the active ingredient contained in Oxyfast) hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using oxycodone and call your doctor at once if you have:

• shallow breathing, slow heartbeat;

• seizure (convulsions);

• cold, clammy skin;

• confusion;

• severe weakness or dizziness; or

• a feeling like you might pass out.

Common side effects may include:

• nausea, vomiting, constipation, loss of appetite;

• dizziness, headache, tired feeling;

• dry mouth;

• sweating; or

• itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to oxycodone: compounding powder, oral capsule, oral concentrate, oral solution, oral tablet, oral tablet extended release

General

In general, the adverse effects that occur with oxycodone (the active ingredient contained in Oxyfast) are similar with the immediate- and controlled-release products. Adverse effects may be dose-related in opioid naive patients. Patients who are tolerant to the analgesic effect of oxycodone may be tolerant to the dose-related side effects, except constipation.

Nervous system

Nervous system side effects are common and include drowsiness (23% to 24%), sedation, dizziness (13% to 16%), headache (7%). dry mouth (7%), and lightheadedness. Many of the central nervous system adverse effects may be minimized by slow titration of the dose.

Respiratory

Respiratory depression may occur with any opioid, including oxycodone (the active ingredient contained in Oxyfast) Other effects may include apnea, respiratory arrest, and rarely circulatory collapse.

Severe adverse effects such as respiratory depression can be treated with the opioid antagonist naloxone. (The usual adult dose of naloxone is 1 to 2 mg every 5 minutes as necessary to a maximum of 10 mg. The dose can be administered intravenously, intramuscularly, subcutaneously, and sublingually.)

Gastrointestinal

Nausea (23% to 27%), vomiting (12% to 14%), and constipation (23% to 26%) occur commonly. There have been rare reports of difficulty in swallowing the tablets, intestinal obstruction, and exacerbation of diverticulitis, some of which have required medical intervention to remove the tablet. Patients with underlying GI disorders such as esophageal cancer or colon cancer with a small gastrointestinal lumen are at greater risk of developing these complications.

Other

Withdrawal symptoms, after either abrupt cessation or fast tapering of narcotic analgesics, may occur and include agitation, palpitations, restlessness, anxiety, insomnia, tremor, abdominal cramps, blurred vision, vomiting, piloerection, and sweating.

Psychosis has also been reported during withdrawal from oxycodone.

Psychiatric

Psychiatric adverse effects reported include paranoia, psychosis, and hallucinations.

Dermatologic

Pruritus has been reported rarely. Diphenhydramine (25 to 50 mg) has been shown to be helpful for opioid-associated pruritus.

Hepatic

Hepatic side effects including increased hepatic enzymes have been reported.

Cardiovascular

Cardiovascular side effects from higher doses have included QTc prolongation.

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