Oxaprozin Side Effects
It is possible that some side effects of oxaprozin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to oxaprozin: oral tablet
As well as its needed effects, oxaprozin may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking oxaprozin, check with your doctor immediately:More common
- Skin rash
- bloody or black, tarry stools
- burning upper abdominal pain
- burning while urinating
- cloudy urine
- decrease in urine output or decrease in urine-concentrating ability
- difficult or painful urination
- frequent urination
- itching skin
- loss of appetite
- nausea or vomiting
- pale skin
- severe abdominal pain, cramping, or burning
- severe and continuing nausea
- troubled breathing with exertion
- unusual bleeding or bruising
- unusual tiredness or weakness
- vomiting of blood or material that looks like coffee grounds
- weight loss
- bleeding gums
- blistering, peeling, loosening of skin
- blurred vision
- body aches or pain
- burning feeling in chest or stomach
- changes in blood pressure
- chest pain
- clay-colored stools
- cough or hoarseness
- cracks in the skin
- dark urine
- difficult or labored breathing
- difficulty swallowing
- dilated neck veins
- ear congestion
- extreme fatigue
- feeling of discomfort
- fever or chills
- fluid-filled skin blisters
- high fever
- hives or welts
- increased sensitivity of skin to sunlight
- increased thirst
- increased volume of pale, dilute urine
- inflammation of joints
- irregular, fast or slow, or shallow breathing
- joint or muscle pain
- large, flat, blue or purplish patches in the skin
- large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- light-colored stools
- loss of heat from the body
- loss of voice
- lower back or side pain
- muscle aches
- muscle twitching
- nasal congestion
- noisy breathing
- pain or burning in throat
- pain or tenderness around eyes and cheekbones
- pale or blue lips, fingernails, or skin
- pinpoint red or purple spots on skin
- pounding in the ears
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid weight gain
- red skin lesions, often with a purple center
- red, irritated eyes
- redness or other discoloration of skin
- redness, swelling, or soreness of tongue
- scaly skin
- severe sunburn
- shortness of breath
- skin thinness
- slow, fast, irregular, pounding, or racing heartbeat or pulse
- sore throat
- sores, ulcers, or white spots on lips or tongue or inside the mouth
- stomach upset
- stuffy or runny nose
- swelling of face, fingers, feet, or lower legs
- swelling or inflammation of the mouth
- swollen lymph glands
- tenderness in stomach area
- tightness in chest
- unpleasant breath odor
- upper right abdominal pain
- yellow eyes or skin
Some oxaprozin side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common
- Acid or sour stomach
- stomach discomfort
- Continuing ringing or buzzing or other unexplained noise in ears
- excess air or gas in stomach or intestines
- hearing loss
- passing gas
- relaxed and calm
- sleepiness or unusual drowsiness
- trouble sleeping
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- burning, dry, or itching eyes
- change in taste
- decreased hearing
- discharge, excessive tearing
- dry mouth
- feeling of constant movement of self or surroundings
- general feeling of discomfort or illness
- lack or loss of strength
- redness, pain, swelling of eye, eyelid, or inner lining of eyelid
- sensation of spinning
- shakiness in legs, arms, hands, feet
- trembling or shaking of hands or feet
- unable to sleep
For Healthcare Professionals
Applies to oxaprozin: oral tablet
Patients with a history of serious gastrointestinal events or alcohol abuse are at increased risk for severe gastrointestinal side effects. Oxaprozin should be used with caution in these patients.
Gastrointestinal side effects associated with oxaprozin include nausea (8%), dyspepsia (8%), diarrhea (3% to 9%), constipation (3% to 9%), anorexia, vomiting, and flatulence. More serious gastrointestinal effects such as peptic ulceration, gastrointestinal bleeding, and rectal bleeding have been reported.
Hepatic side effects include elevations in serum transaminases in up to 12% of patients. Hepatitis has been reported in less than 1% of patients. A case of fatal, fulminant hepatitis has been reported with oxaprozin use.
Elevations in liver function tests three times normal values occurred in 1.4% of patients treated with oxaprozin.
While oxaprozin-induced elevations in liver function tests are usually mild and transient, fatal hepatitis has been reported with oxaprozin. Patients who develop persistent or significant elevations in liver function tests and/or signs or symptoms suggestive of hepatic dysfunction should be evaluated for more severe hepatotoxicity.
Renal side effects include interstitial nephritis, membranous nephropathy, hematuria, nephrotic syndrome, oliguria/polyuria, proteinuria, and acute renal failure.
Oxaprozin may impair the ability of the kidney to cope with low renal blood flow states due to inhibition of prostaglandin-dependent afferent arteriolar vasodilation. Renal function may be further compromised in patients with heart failure, hypovolemia, cirrhosis, nephrotic syndrome, or hypoalbuminemia. Additional risk factors for oxaprozin-induced renal insufficiency are advanced age and concomitant use of diuretics.
A case-control study suggested that patients who consumed 5000 or more pills containing NSAIDs during their lifetime may be at increased risk of end-stage renal disease.
Cardiovascular side effects have included fluid retention and edema which may be important in patients with heart failure. In addition, blood pressure may be elevated by oxaprozin which may have clinical relevance in patients with comorbid illnesses.
Nonsteroidal anti-inflammatory drugs (NSAIDs) may elevate blood pressure and increase the risk for the initiation of antihypertensive therapy. Furthermore, NSAIDs may antagonize the blood pressure lowering effect of antihypertensive medications in patients already being treated with antihypertensive drugs.
Nervous system side effects have included depression (i.e. sedation, somnolence, confusion, and depression), sleep disturbances, weakness, fatigue, headache, and vertigo have been reported.
Dermatologic side effects have included rash (3% to 9%), alopecia, pruritus, exfoliative dermatitis, pseudoporphyria, erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis (Lyell's syndrome). Photosensitivity characterized by vesicular eruptions has been reported. Pseudoporphyria, or bullous photosensitivity, has also been reported. Angioedema and sweat have been reported in patients taking other NSAIDs.
Hematologic side effects have included agranulocytosis, pancytopenia, anemia, thrombocytopenia, leukopenia, and ecchymoses. Prolonged bleeding time may occur as well.
Hypersensitivity reactions occur in less than 1% of patients and may manifest as urticaria and anaphylaxis.
Other side effects of oxaprozin include tinnitus, blurred vision, and conjunctivitis. In addition, oxaprozin may cause a false positive result on urine drug screening for benzodiazepines.
Psychiatric disturbances, including confusion, delusions, depression, hallucinations, paranoid reactions, and panic disorders, although rare, have been noted with oxaprozin use.
Genitourinary side effects have included an increase or decrease in menstrual flow in less than 1% of patients.
Respiratory side effects (<1%) have included asthma, dyspnea, respiratory depression, sinusitis, symptoms of upper respiratory tract infection, pulmonary infections, and pneumonia.
More about oxaprozin
- Other brands: Daypro
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