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Otimar Side Effects

Generic Name: hydrocortisone / neomycin / polymyxin b otic

Note: This page contains side effects data for the generic drug hydrocortisone / neomycin / polymyxin b otic. It is possible that some of the dosage forms included below may not apply to the brand name Otimar.

It is possible that some side effects of Otimar may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to hydrocortisone / neomycin / polymyxin b otic: otic solution, otic suspension

As well as its needed effects, hydrocortisone / neomycin / polymyxin b otic may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking hydrocortisone / neomycin / polymyxin b otic, check with your doctor immediately:

More common
  • Itching, skin rash, redness, swelling, or other sign of irritation in or around the ear not present before use of this medicine

For Healthcare Professionals

Applies to hydrocortisone / neomycin / polymyxin b otic: otic solution, otic suspension


Hypersensitivity reactions associated with the anti-infective component of this drug include allergic sensitization manifested by itching and swelling. More serious reactions such as anaphylaxis have rarely been reported.[Ref]

Neomycin is known to cause contact sensitivity.[Ref]


Dermatologic side effects associated with the use of topical corticosteroids have included burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, and miliaria.[Ref]


Stinging and burning have been rarely reported when this drug has entered the middle ear.[Ref]

Nervous system

Neomycin-polymyxin B containing ear drops contributed to sensorineural hearing loss in chronic otitis media patients receiving treatment for extended periods of time.[Ref]


1. Prystowsky SD, Allen AM, Smith RW, Nonomura JH, Odom RB, Akers WA "Allergic contact hypersensitivity to nickel, neomycin, ethylenediamine, and benzocaine. Relationships between age, sex, history of exposure, and reactivity to standard patch tests and use tests in a general population." Arch Dermatol 115 (1979): 959-62

2. Prystowsky SD, Nonomura JH, Smith RW, Allen AM "Allergic hypersensitivity to neomycin. Relationship between patch test reactions and 'use' tests." Arch Dermatol 115 (1979): 713-5

3. "Product Information. Cortisporin Otic (hydrocortisone/neomycin/polymyxin B otic)" Monarch Pharmaceuticals Inc, Bristol, TN.

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