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Oseni Side Effects

Generic Name: alogliptin / pioglitazone

Note: This page contains side effects data for the generic drug alogliptin / pioglitazone. It is possible that some of the dosage forms included below may not apply to the brand name Oseni.

It is possible that some side effects of Oseni may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to alogliptin / pioglitazone: oral tablet

As well as its needed effects, alogliptin / pioglitazone may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking alogliptin / pioglitazone, check with your doctor immediately:

More common
  • Anxiety
  • blurred vision
  • chest pain
  • chills
  • cold sweats
  • coma
  • confusion
  • cool, pale skin
  • decreased urine output
  • depression
  • dilated neck veins
  • dizziness
  • extreme fatigue
  • fast heartbeat
  • headache
  • increased hunger
  • irregular breathing
  • irregular heartbeat
  • nausea
  • nightmares
  • seizures
  • shakiness
  • slurred speech
  • swelling of the face, fingers, feet, or lower legs
  • tightness in the chest
  • troubled breathing
  • unusual tiredness or weakness
  • weight gain
  • Blistering, peeling, or loosening of the skin
  • bloating
  • blood in the urine
  • constipation
  • cough
  • darkened urine
  • diarrhea
  • difficulty with swallowing
  • feeling of discomfort
  • fever
  • frequent, strong, or increased urge to urinate
  • hives
  • indigestion
  • inflammation of the joints
  • itching
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • muscle aches
  • pain in the back, lower abdomen, or stomach
  • painful urination
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rash
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • swollen lymph glands
  • vomiting
  • yellow eyes or skin
Incidence not known
  • Change in vision
  • general feeling of tiredness or weakness
  • light-colored stools
  • stomach pain, continuing

Some alogliptin / pioglitazone side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common
  • Back pain
  • body aches or pain
  • ear congestion
  • loss of voice
  • sneezing
  • stuffy or runny nose

For Healthcare Professionals

Applies to alogliptin / pioglitazone: oral tablet


The most common side effect reported include nasopharyngitis, back pain and upper respiratory tract infection.[Ref]


Common (1% to 10%): Hypertension (2.3%)

Common (1% to 10%): Congestive heart failure (CHF) (8.2%), at least one hospitalized CHF event (5.7%), hospitalization for worsening CHF (4.7%), non-fatal, hospitalized CHF (4.7%), death due to cardiovascular causes (2.3%), emergency room visit for CHF (1.2%), fatal CHF (1%)
Postmarketing reports: Congestive heart failure (with and without known heart disease and with and without concomitant insulin)[Ref]


Common (1% to 10%): Hypoglycemia (up to 4.5%)

Common (1% to 10%): Hypoglycemia (up to 5.4%)

Common (1% to 10%): Hypoglycemia (up to 4.7%)[Ref]


Uncommon (0.1% to 1%): Pancreatitis (0.2%)
Postmarketing reports: Acute pancreatitis[Ref]


Uncommon (0.1% to 1%): Elevated ALT (0.3%)
Frequency not reported: Decreased hemoglobin and hematocrit[Ref]


Postmarketing reports: Hepatic enzyme elevations, fulminant hepatic failure

Uncommon (0.1% to 1%): Elevated serum alanine aminotransferase (ALT) (0.3%)
Postmarketing reports: Fatal and non-fatal hepatic fail[Ref]


Uncommon (0.1% to 1%): Hypersensitivity reactions (0.6%)
Postmarketing reports: Anaphylaxis, angioedema, rash, urticaria, severe cutaneous adverse reactions (Stevens-Johnson syndrome)[Ref]


Frequency not reported: Weight gain, edema
Postmarketing reports: Rapid increased in weight[Ref]


Common (1% to 10%): Back pain (4.2%)

Common (1% to 10%): Back pain (2%)
Frequency not reported: Arthralgia

Common (1% to 10%): Myalgia (5.4%), back pain (3.4%)
Uncommon (0.1% to 1%): Elevation in serum creatine phosphokinase (CPK) (0.2%)[Ref]

Alogliptin: Between October 2006 and December 2013, thirty-three cases of severe arthralgia have been reported to the FDA Adverse Event Reporting System Database. Each case involved the use of 1 or more dipeptidyl peptidase-4 (DPP-4) inhibitor. In all cases, substantial reduction in prior activity level was reported, 10 patients were hospitalized due to disabling joint pain. In 22 cases, symptoms appeared within 1 month of starting therapy, in 23 cases symptoms resolved less than 1 month after discontinuation. A positive rechallenge was reported in 8 cases, with 6 cases involving use of a different DPP-4 inhibitor. Sitagliptin had the greatest number of cases reported (n=28) followed by saxagliptin (n=5), linagliptin (n=2), alogliptin (n=1), and vildagliptin (n=2).[Ref]

Nervous system

Common (1% to 10%): Headache (4.2%)

Common (1% to 10%): Headache (9.1%)[Ref]


Postmarketing reports: Macular edema[Ref]


Uncommon (0.1% to 1%): Bladder cancer (up to 0.44%)[Ref]


Very common (10% or more): Nasopharyngitis (4.9%), upper respiratory tract infection (4.1%)

Common (1% to 10%): Influenza (5.5%), nasopharyngitis (4.7%), upper respiratory tract infection (4.3%)

Common (1% to 10%): Upper respiratory tract infection (up to 13.2%), sinusitis (6.3%), nasopharyngitis (3.9%)[Ref]


1. "Product Information. Oseni (alogliptin-pioglitazone)." Takeda Pharmaceuticals America, Lincolnshire, IL.

2. US Food and Drug Administration "FDA Drug Safety Communication: FDA warns that DPP-4 inhibitors for type 2 diabetes may cause severe joint pain. Available from: URL:" ([2015, Aug 28]):

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