Orphenate Side Effects
Generic Name: orphenadrine
Note: This page contains side effects data for the generic drug orphenadrine. It is possible that some of the dosage forms included below may not apply to the brand name Orphenate.
It is possible that some side effects of Orphenate may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
For the Consumer
Applies to orphenadrine: oral tablet, oral tablet extended release
Other dosage forms:
As well as its needed effects, orphenadrine (the active ingredient contained in Orphenate) may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking orphenadrine, check with your doctor immediately:Rare
- Chest pain
- hallucinations (seeing, hearing, or feeling things that are not there)
- shortness of breath, troubled breathing, tightness in chest, and/or wheezing
- skin rash, hives, itching, or redness
- sores, ulcers, or white spots on lips or in mouth
- swollen and/or painful glands
- unusual bruising or bleeding
- unusual tiredness or weakness
- Abdominal or stomach pain
- fast, pounding irregular heartbeat or pulse
- joint or muscle pain
- numbness or tingling of face, hands, or feet
- redness and soreness of eyes
- swelling of feet or lower legs
If any of the following symptoms of overdose occur while taking orphenadrine, get emergency help immediately:Symptoms of Overdose
- Blurred vision
- confusion, delirium, or hallucinations
- difficult urination
- dry eyes, mouth, nose, or throat
- eye pain
- flushing or redness of face
- troubled breathing
Some orphenadrine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:Less common or rare
- Dizziness or lightheadedness
- excitement, irritability, nervousness, or restlessness
- muscle weakness
- unusually large pupils of eyes
- deep or fast breathing with dizziness
- itching skin
- mental confusion
- numbness of feet, hands and around mouth
- trembling or shaking of hands or feet shakiness in legs, arms, hands, or feet
For Healthcare Professionals
Applies to orphenadrine: compounding powder, injectable solution, oral tablet extended release
Nervous system side effects have included headache, light-headedness, dizziness, drowsiness, syncope and tremor. Infrequently, elderly patients have experienced mental confusion.
Ocular side effects have included blurred vision, dilatation of pupils, and increased ocular tension.
Cardiovascular side effects have included tachycardia and palpitations.
Genitourinary side effects have included urinary hesitancy and retention.
Gastrointestinal side effects have included dry mouth, nausea, vomiting, and gastric irritation.
Musculoskeletal side effects have included weakness.
Dermatologic side effects have included pruritus, and rarely, urticaria and other dermatosis.
Psychiatric side effects have included hallucinations and agitation.
Hematologic side effects have included very rare cases of aplastic anemia, however, no causal relationship has been established.
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