Orphenate Side Effects

Generic name: orphenadrine

Note: This document contains side effect information about orphenadrine. Some of the dosage forms listed on this page may not apply to the brand name Orphenate.

Some side effects of Orphenate may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to orphenadrine: oral tablet extended release

Get emergency medical help if you have any of these signs of an allergic reaction while taking orphenadrine (the active ingredient contained in Orphenate) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using orphenadrine and call your doctor at once if you have any of these serious side effects:

• fast, pounding, or uneven heartbeats;

• confusion, anxiety, agitation, tremors, hallucinations;

• seizure (convulsions); or

• urinating less than usual or not at all.

Less serious side effects of orphenadrine may include:

• dry mouth or throat;

• blurred vision, dilated pupils;

• headache;

• drowsiness, dizziness;

• nausea, vomiting, constipation; or

• weakness.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

For Healthcare Professionals

Applies to orphenadrine: compounding powder, injectable solution, oral tablet extended release

Nervous system

Nervous system side effects have included headache, light-headedness, dizziness, drowsiness, syncope and tremor. Infrequently, elderly patients have experienced mental confusion.

Ocular

Ocular side effects have included blurred vision, dilatation of pupils, and increased ocular tension.

Cardiovascular

Cardiovascular side effects have included tachycardia and palpitations.

Genitourinary

Genitourinary side effects have included urinary hesitancy and retention.

Gastrointestinal

Gastrointestinal side effects have included dry mouth, nausea, vomiting, and gastric irritation.

Musculoskeletal

Musculoskeletal side effects have included weakness.

Dermatologic

Dermatologic side effects have included pruritus, and rarely, urticaria and other dermatosis.

Psychiatric

Psychiatric side effects have included hallucinations and agitation.

Hematologic

Hematologic side effects have included very rare cases of aplastic anemia, however, no causal relationship has been established.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.