Orinase Side Effects

Generic Name: tolbutamide

Please note - some side effects for Orinase may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects by Body System

Gastrointestinal

Gastrointestinal side effects have included nausea, epigastric fullness, heartburn, and taste alterations.

Hepatic

Hepatic side effects have rarely included cholestatic jaundice. Tolbutamide should be discontinued if this occurs.

Dermatologic

Dermatologic side effects have included pruritus, erythema, urticaria, and morbilliform or maculopapular eruptions. Photosensitivity and porphyria cutanea tarda have been reported with the use on sulfonylureas.

Hematologic

Hematological side effects have included leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, aplastic anemia, and pancytopenia.

Metabolic

Metabolic side effects have included hepatic porphyria and disulfiram-like reactions.

Endocrine

Endocrine side effects have included hyponatremia and the syndrome of inappropriate antidiuretic hormone (SIADH) secretion.

Nervous system

Nervous system side effects have included headache.

Local

Local side effects have included pain and/or a burning sensation at the injection site. Thrombophlebitis with thrombosis of the injected vein has also been reported.

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